Bacterial Vaccines and Serotype Replacement: Lessons from Haemophilus influenzae and Prospects for Streptococcus pneumoniae
Figure 2. Carriage of three serotypes of Haemophilus influenzae in children vaccinated against serotype b (black bars) and in controls (white bars) (14). Error bars indicate 95% confidence interval (binomial approximation). Shaded bars show the maximum carriage of serotypes e and f in vaccine recipients that could result from replacement in a population where only a small proportion of susceptibles are vaccinated (as in the study). Striped bars show the equivalent figures in a hypothetical study in which virtually all susceptibles were vaccinated.