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Volume 5, Number 5—October 1999


Influence of Host Genetics on the Severity of Coccidioidomycosis

Leslie Louie*Comments to Author , Susanna Ng*, Rana Hajjeh†, Royce Johnson‡, Duc J. Vugia§, S. Benson Werner§, Ronald Talbot¶, and William Klitz*
Author affiliations: *University of California, Berkeley, California, USA; †Centers for Disease Control and Prevention, Atlanta, Georgia, USA; ‡Kern Medical Center, Bakersfield, California, USA; §California Department of Health Services, Berkeley, California, USA; ¶Kern County Public Health Department, Bakersfield, California, USA

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Table 2

Hardy-Weinberg test results (p values) for HLA class II loci, by ethnicity and severity of diseasea

Hispanic, Severe 0.34 0.18 0.38 0.27 50
Hispanic, Mild 0.12 0.11 0.002 0.045 32
Caucasian, Severe 0.09 0.14 0.38 0.008 27
Caucasian, Mild 0.12 0.14 0.11 0.022 50
African-American, Severe 0.63 0.80 0.67 0.31 2

aNumbers in bold indicate alleles not in Hardy-Weinberg equilibrium for a particular group and locus.

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