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Volume 5, Number 5—October 1999

Research

Influence of Host Genetics on the Severity of Coccidioidomycosis

Leslie Louie*Comments to Author , Susanna Ng*, Rana Hajjeh†, Royce Johnson‡, Duc Vugia§, S. Benson Werner§, Ronald Talbot¶, and William Klitz*
Author affiliations: *University of California, Berkeley, California, USA; †Centers for Disease Control and Prevention, Atlanta, Georgia, USA; ‡Kern Medical Center, Bakersfield, California, USA; §California Department of Health Services, Berkeley, California, USA; ¶Kern County Public Health Department, Bakersfield, California, USA

Main Article

Table 3

Blood group antigen frequencies for coccidioidomycosis, by ethnicity and severity of disease

Phenotype
Ethnic group A AB B O N
Hispanica Severe 0.24 0.02 0.12 0.62 50
Mild 0.53 0.00 0.00 0.47 32
Controlsb 0.13 0.04 0.27 0.56 335
Caucasian Severe 0.48 0.04 0.04 0.44 27
Mild 0.46 0.02 0.12 0.40 50
Controlsb 0.41 0.03 0.11 0.45 8,962
African- Severe 0.12 0.04 0.16 0.68 25
American Controlsb 0.28 0.04 0.19 0.50 1,540

aABO phenotype distribution for cases and controls among Hispanics, p < 0.001
bPopulation control frequencies from Mourant, 1976 (17)

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