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Volume 5, Number 5—October 1999

Dispatch

Diphtheria Antitoxin Levels in the Netherlands: a Population-Based Study

Hester E. de MelkerComments to Author , G.A.M. Berbers, N.J.D. Nagelkerke, and M.A.E. Conyn-van Spaendonck
Author affiliations: National Institute of Public Health and the Environment, Bilthoven, the Netherlands

Main Article

Table 3

Age-specific prevalence of diphtheria immunity and geometric mean titers for children £ 14 years of age and for men and women ≤79 years of age in a nationwide sample, the Netherlands

Age group
(yrs) <0.01 IU/ml 0.01-0.1 IU/ml ≥0.1 IU/ml Geometric mean titer
No. (95% CIa) (95% CI) (95% CI) (95% CI)
<1 187 3.7 (1.1-6.4) 25.5 (18.6-32.4) 70.7 (63.4-78.1) 0.19 (0.15-0.24)
1 185 1.2 (0.0-3.0) 9.9 (5.4-14.3) 88.9 (84.3-93.5) 0.57 (0.45-0.72)
2 156 1.9 (0.1-3.7) 34.9 (24.2-45.5) 63.3 (52.9-73.6) 0.15 (0.12-0.19)
3 215 1.7 (0.1-3.3) 35.5 (27.7-43.3) 62.8 (54.7-70.9) 0.16 (0.12-0.22)
4 153 0.6 (0.0-1.7) 8.7 (3.7-13.7) 90.7 (85.7-95.7) 0.81 (0.60-1.10)
5 102 1.4 (0.0-3.3) 6.3 (1.9-10.7) 92.3 (87.7-97.0) 0.43 (0.35-0.52)
6 121 0.9 (0.0-2.6) 20.0 (11.7-28.3) 79.1 (70.9-87.4) 0.26 (0.21-0.34)
7 101 2.3 (0.0-5.4) 31.8 (20.3-43.3) 65.9 (54.7-77.2) 0.16 (0.13-0.20)
8 127 0.7 (0.0-2.0) 23.6 (14.9-32.3) 75.8 (66.9-84.6) 0.28 (0.20-0.38)
9 97 0.0 (0.0-0.0) 11.8 (3.2-20.4) 88.2 (79.6-96.8) 0.71 (0.51-0.99)
10 113 0.7 (0.0-2.1) 6.7 (1.9-11.5) 92.6 (87.7-97.5) 0.54 (0.42-0.69)
11 111 0.7 (0.0-1.9) 8.3 (3.5-13.2) 91.0 (85.8-96.2) 0.36 (0.30-0.44)
12 122 0.6 (0.0-1.9) 17.0 (9.2-24.8) 82.4 (74.2-90.5) 0.28 (0.22-0.35)
13 126 0.0 (0.0-0.0) 27.3 (18.0-36.7) 72.7 (63.3-82.0) 0.23 (0.18-0.29)
14 102 0.4 (0.0-1.1) 26.7 (14.0-39.3) 72.9 (60.3-85.6) 0.22 (0.15-0.31)
Men
<1 104 3.5 (0.04-7.0) 25.2 (15.8-34.6) 71.3 (61.4-81.2) 0.18 (0.13-0.24)
1-4 376 1.8 (0.5-3.1) 22.9 (17.0-28.8) 75.3 (69.1-81.5) 0.31 (0.25-0.38)
5-9 296 0.6 (0.0-1.4) 16.9 (12.4-21.4) 82.5 (77.9-87.1) 0.34 (0.28-0.40)
10-14 280 0.6 (0.0-1.7) 16.5 (11.7-21.3) 83.0 (78.0-88.0) 0.32 (0.27-0.38)
15-19 209 1.0 (0.0-2.4) 25.8 (19.7-31.9) 73.1 (67.1-79.1) 0.19 (0.16-0.23)
20-24 139 4.0 (0.4-7.6) 25.5 (17.8-33.2) 70.5 (62.0-79.0) 0.15 (0.12-0.19)
25-29 150 2.9 (0.0-6.2) 30.6 (21.7-39.5) 66.5 (56.9-76.1) 0.18 (0.14-0.24)
30-34 188 7.0 (1.6-12.4) 31.5 (23.0-40.0) 61.5 (52.1-70.9) 0.14 (0.10-0.19)
35-39 220 5.1 (1.3-8.9) 27.4 (20.7-34.1) 67.5 (60.8-74.2) 0.18 (0.14-0.23)
40-44 230 3.8 (1.1-6.5) 16.3 (11.0-21.6) 79.9 (73.9-85.9) 0.25 (0.20-0.31)
45-49 208 13.7 (7.8-19.6) 26.6 (21.4-31.8) 59.7 (51.8-67.6) 0.13 (0.09-0.18)
50-54 228 15.0 (10.4-19.6) 31.1 (24.7-37.5) 53.9 (46.5-61.3) 0.10 (0.08-0.13)
55-59 251 8.8 (4.0-13.6) 38.8 (32.1-45.5) 52.4 (46.0-58.8) 0.10 (0.08-0.12)
60-64 216 10.3 (6.2-14.4) 52.3 (43.8-60.8) 37.4 (29.9-44.9) 0.07 (0.06-0.09)
65-69 200 26.5 (19.6-33.4) 39.4 (30.4-48.4) 34.1 (26.2-42.0) 0.05 (0.04-0.06)
70-74 193 46.2 (36.9-55.5) 26.6 (19.2-34.0) 27.1 (19.2-35.2) 0.03 (0.02-0.04)
75-79 156 45.0 (35.8-54.2) 26.2 (17.8-34.6) 28.8 (20.8-36.8) 0.03 (0.02-0.04)
Women
<1 83 4.2 (0.0-8.9) 26.6 (13.7-39.5) 69.3 (56.7-81.9) 0.19 (0.13-0.27)
1-4 333 2.2 (0.5-3.9) 22.2 (16.7-27.7) 75.6 (70.0-81.2) 0.30 (0.25-0.37)
5-9 252 1.8 (0.0-3.7) 23.8 (16.2-31.4) 74.5 (68.2-80.8) 0.29 (0.24-0.36)
10-14 294 0.3 (0.0-0.8) 18.6 (12.9-24.3) 81.1 (75.4-86.8) 0.29 (0.24-0.33)
15-19 243 0.7 (0.0-1.7) 28.2 (21.9-34.5) 71.1 (64.8-77.4) 0.17 (0.15-0.20)
20-24 199 2.8 (0.4-5.2) 31.3 (23.6-39.0) 65.9 (58.3-73.5) 0.14 (0.12-0.18)
25-29 226 5.0 (1.5-8.5) 27.1 (20.3-33.9) 67.9 (60.5-75.3) 0.14 (0.11-0.18)
30-34 244 10.0 (5.7-14.3) 36.9 (30.5-43.3) 53.0 (47.3-58.7) 0.11 (0.09-0.13)
35-39 282 5.6 (2.5-8.7) 37.0 (29.6-44.4) 57.4 (50.6-64.2) 0.13 (0.11-0.15)
40-44 247 8.7 (4.8-12.6) 24.4 (18.5-30.3) 66.9 (60.9-72.9) 0.16 (0.12-0.20)
45-49 261 22.0 (15.8-28.2) 37.6 (30.6-44.6) 40.3 (32.3-48.3) 0.06 (0.04-0.08)
50-54 264 28.2 (20.2-36.2) 41.7 (34.5-48.9) 30.1 (23.0-37.2) 0.04 (0.03-0.05)
55-59 250 22.3 (16.3-28.3) 49.7 (43.6-55.8) 28.0 (22.3-33.7) 0.04 (0.03-0.05)
60-64 237 29.2 (22.9-35.5) 45.9 (39.7-52.1) 24.8 (19.0-30.6) 0.03 (0.02-0.04)
65-69 263 38.0 (30.6-45.4) 34.3 (29.0-39.6) 27.7 (21.3-34.1) 0.03 (0.02-0.05)
70-74 218 58.2 (50.8-65.6) 25.0 (18.9-31.1) 16.8 (11.0-22.6) 0.02 (0.01-0.02)
75-79 175 52.7 (43.8-61.6) 26.6 (19.4-33.8) 20.7 (12.7-28.7) 0.02 (0.01-0.03)

aCI, confidence interval.

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