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Volume 5, Number 6—December 1999

Dispatch

Effectiveness of Pneumococcal Polysaccharide Vaccine for Preschool-Age Children with Chronic Disease

Anthony E. FioreComments to Author , Orin S. Levine, John A. Elliott, Richard R. Facklam, Jay C. Butler, and for the Pneumococcal Sentinel Surveillance Working Group
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Main Article

Table

Estimates of pneumococcal polysaccharide vaccine effectiveness among 173 children 2 through 5 years of age, using the indirect cohort method

Vaccine serotype/total(%)
Group Vaccinated childrena Unvaccinated childrena Effectiveness (95% CI)b
All children 35/48 (73) 110/125 (88) 63% (8% to 85%)
Children with SCD 27/33 (82) 12/13 (92) 62% (-294% to 98%)
Children without SCD 8/15 (53) 98/112 (88) 84% (40% to 96%)
Nonconjugate vaccine serotypec 1/14 (7) 18/33 (55) 93% (45% to 100%)

a23-valent pneumococcal polysaccharide vaccine.
bEffectiveness (95% confidence interval) estimated as (1- odds ratio or 95% confidence bound) x 100%.
cChildren infected with a serotype not in proposed conjugate vaccine (15) (excludes children infected with serotypes 4, 6B, 9V, 14, 18C, 19F, 23F).
SCD, sickle-cell disease.

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