The bdr Gene Families of the Lyme Disease and Relapsing Fever Spirochetes: Potential Influence on Biology, Pathogenesis, and Evolution
David M. Roberts*, Jason A Carlyon†, Michael Theisen, and Richard T. Marconi*
Author affiliations: *Medical College of Virginia at Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA; †Yale School of Medicine, Yale University, New Haven, Connecticut, USA; ‡Statens Serum Institute, Copenhagen, Denmark
Figure 3. Key features and putative functional domains of the Bdr proteins. The schematic depicts a prototype Bdr protein with the characteristics of each domain indicated. The abbreviation, ID%, is for percentage amino acid identity at either the inter- or intra-family level as indicated in the figure. Standard amino acid abbreviations are used in the figure to denote the conserved C-terminal lysine (K) or asparagine (N) residues, which are thought to be exposed in the periplasm and the cytoplasmically located core tripeptide of the repeat motif (lysine-isoleucine-aspartic acid; KID).
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