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Volume 6, Number 2—April 2000

Research

Serologic Response to Culture Filtrate Antigens of Mycobacterium ulcerans during Buruli Ulcer Disease

Karen M. Dobos*†, Ellen A. Spotts*†, Barbara J. Marston*, C. Robert Horsburgh*, and C. Harold King*Comments to Author 
Author affiliations: *Emory University School of Medicine, Atlanta, Georgia, USA; and †Centers for Disease Control and Prevention, Atlanta, Georgia, USA

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Table 1

Burulin skin test responses of Buruli ulcer patients and healthy controls from the same villages

Clinical presentation Burulin
(+) only Dual
(+) PPD
(+) only Dual
(-)
Total BU patients
(n = 39) (%)  17 (43.6) 11 (28.2) 6 (15.4) 5 (12.8)
Healed
(n = 16) (%) 9 (56.3) 6 (37.5) 1 (6.2) 0 (0.0)
Ulcerative
(n = 17) (%) 7 (41.2) 4 (23.5) 4 (23.5) 2 (11.8)
Early ulcerative
(n = 6) (%) 1 (16.7) 1 (16.7) 1 (16.7) 3 (50)
No scar or ulcer
(n = 21) (%) 3 (14.3) 0 (0.0) 1 (4.8) 17 (81)

Each column provides the number (n) and percentage (%) of persons meeting the criteria for specific skin-test positivity. Dual (+) persons, being both PPD and Burulin (+), are not exclusive for either Burulin or PPD positivity and thus are not included in either of these two columns.
Persons were scored Burulin-only skin-test positive if the diameter of induration at the site of Burulin injection was 10 mm at 48 or 72 hours and the diameter of induration at the site of PPD injection was at least 3 mm smaller than in the Burulin response. Persons were scored as only PPD positive if the diameter of induration at the site of PPD injection was 10 mm at 48 or 72 hours and the diameter of induration at the site of Burulin injection was at least 3 mm smaller than that in the PPD response. Persons were scored as both Burulin and PPD skin-test positive if the diameters of induration of both the Burulin and PPD injection sites were 10 mm at 48 or 72 hours and the differences in the diameters of the zone of induration between the two was <3 mm. Persons were scored as skin test negative for both if the induration at both injection sites was <10 mm at 48 or 72 hours.

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