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Volume 6, Number 2—April 2000

Research

Serologic Response to Culture Filtrate Antigens of Mycobacterium ulcerans during Buruli Ulcer Disease

Karen M. Dobos*†, Ellen A. Spotts*†, Barbara J. Marston*, C. Robert Horsburgh*, and C. Harold King*Comments to Author 
Author affiliations: *Emory University School of Medicine, Atlanta, Georgia, USA; and †Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Main Article

Table 3

Antibody responses to specific Mycobacterium ulcerans culture filtrate proteins in all Buruli ulcer patients and controls

Clinical Presentation 5 kDa (%) 36/38 kDa (%) 70 kDa (%) All Three (%) Any (%)a
Total BU patients
(n= 61) (%) 14 (22.9) 31 (50.8) 37 (60.7) 8 (13.1) 43 (70.5)
Healed
(n = 29) 8 (27.6) 15 (51.7) 17 (58.6) 7 (24.1) 20 (69.0)
Ulcerative
(n = 22) 6 (27.3) 10 (45.5) 14 (63.6) 2 (9.1) 16 (72.7)
Early ulcerative
(n=10) (%) 0 (0.0) 6 (60.0) 6 (60.0) 0 (0.0) 7 (70.0)
No scar or ulcer
(n= 27) (%) 7 (25.9) 4 (14.8) 3 (11.1) 1 (3.7) 10 (37.0)
U.S. TB patients
(n= 13) (%) 3 (23.1) 3 (23.1) 0 (0.0) 0 (0.0) 4 (30.8)

aDenotes total number (percentage) of persons within the population with an antibody response to any one, or a mixture of, the three specified MUCF proteins. MUCF = Mycobacterium ulcerans culture filtrate

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