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Volume 6, Number 5—October 2000

Research

Toxin Gene Expression by Shiga Toxin-Producing Escherichia coli: the Role of Antibiotics and the Bacterial SOS Response

Patrick T. Kimmitt, Colin R. Harwood, and Michael R. BarerComments to Author 

Author affiliations: The Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom

Article in Chinese

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Figure 2

Dose-response characteristics of antibiotic-induced expression of stx2::lacZ. Exponential-phase inocula were exposed to antibiotics for 4 h (white bars) or 24 h (black bars), and β-galactosidase activity was determined at the end of these periods. Fold-increase = Test activity (+ antibiotic) / control activity (- antibiotic). Note the difference in scale between upper and lower panels. *MICs refer to the antibiotic concentrations required to inhibit growth in the Bioscreen system, using the same

Figure 2. Dose-response characteristics of antibiotic-induced expression of stx2::lacZ. Exponential-phase inocula were exposed to antibiotics for 4 h (white bars) or 24 h (black bars), and β-galactosidase activity was determined at the end of these periods. Fold-increase = Test activity (+ antibiotic) / control activity (- antibiotic). Note the difference in scale between upper and lower panels. *MICs refer to the antibiotic concentrations required to inhibit growth in the Bioscreen system, using the same inoculation pattern as in the antibiotic induction experiments. The values were cefuroxime 10 g/L, furazolidone 32 g/L, trimethoprim 0.6 g/L and ofloxacin 0.05 g/L.

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