Emerging Infectious Disease ISSN: 1080-6059

Evidence Against Rapid Emergence of Praziquantel Resistance in Schistosoma haematobium, Kenya

Charles H. King*, Eric M. Muchiri†, and John H. Ouma†

Author affiliations: *Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio, USA; †Ministry of Health, Nairobi, Kenya

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Figure 4

a. Hardy-Weinberg equilibrium analysis of the increase in resistance gene frequency in a parasite population where the initial R gene frequency is 10-6, heterozygotes and R gene homozygotes are fully resistant, and 75% of susceptible worms are lost to treatment each generation. b. As in a, but 40% of heterozygotes are lost to treatment each generation. c. As in a, but 99% of resistant homozygotes do not survive to reproduce.

Figure 4. a. Hardy-Weinberg equilibrium analysis of the increase in resistance gene frequency in a parasite population where the initial R gene frequency is 10^-6, heterozygotes and R gene homozygotes are fully resistant, and 75% of susceptible worms are lost to treatment each generation. b. As in a, but 40% of heterozygotes are lost to treatment each generation. c. As in a, but 99% of resistant homozygotes do not survive to reproduce.

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