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Volume 6, Number 6—December 2000

Perspective

Evidence Against Rapid Emergence of Praziquantel Resistance in Schistosoma haematobium, Kenya

Charles H. King*, Eric M. Muchiri†, and John H. Ouma†
Author affiliations: *Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio, USA; †Ministry of Health, Nairobi, Kenya

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Figure 5

Three-dimensional graph of estimated mean community level of infection over time (20 years) as a function of the proportion of infections treated each year (20% to 100%). Results are obtained from the model described in the Appendix. Resurgence of infection (due to emergence of resistance) was predicted to occur soonest (≈7 years) when yearly treatment coverage was greatest (100%). Under the conditions of our study (25% to 75% coverage), detectable increases in community level of infection (due

Figure 5. Three-dimensional graph of estimated mean community level of infection over time (20 years) as a function of the proportion of infections treated each year (20% to 100%). Results are obtained from the model described in the Appendix. Resurgence of infection (due to emergence of resistance) was predicted to occur soonest (≈7 years) when yearly treatment coverage was greatest (100%). Under the conditions of our study (25% to 75% coverage), detectable increases in community level of infection (due to resistance) were estimated to take a minimum of 10 to 15 years.

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