Volume 6, Number 6—December 2000
Perspective
Evidence Against Rapid Emergence of Praziquantel Resistance in Schistosoma haematobium, Kenya
Table 1
Effectiveness of praziquantel (PZQ) in eliminating Schistosoma haematobium infection, Msambweni, Coast Province, Kenya, 1984–1992
| Patient's infection and treatment status | 1984 | 1985 | 1986 | 1987 | 1989 | 1990 | 1991 |
|---|---|---|---|---|---|---|---|
| Egg-positive urine, Given PZQ, never previously treated | 17% (97 to 1.5) n = 981 | 12% (33 to 1.5) n = 51 | 34% (29 to 3.7) n = 82 | - | 15% (18 to 1.5) n = 352 | 4% (22 to 1.1) n = 292 | 35% (24 to 4) n = 274 |
| Egg-positive urine, Given PZQ, had 1 PZQ treatments | - | 13% (10 to 1.5) n = 111 | 38% (16 to 2.6) n = 47 | - | 10% (19 to 1.1) n = 68 | 2% (14 to 1.0) n = 73 | 29% (13 to 2.8) n = 64 |
| All egg-positive, PZQ-treated patients | 17% (97 to 1.5) n = 981 | 13% (15 to 1.5) n = 162 | 35% (24 to 3.3) n = 129 | - | 14% (19 to 1.4) n = 420 | 4% (20 to 1.1) n = 365 | 34% (22 to 3.8) n = 338 |
| Infection rate (egg - to egg + conversion) | 15% | 9% | 11% | 11% | 13% | 10% | 21% |
| All patients, treated and untreated | 18% n = 3,196 | 12% n =2,498 | 14% n = 2,372 | 19% n = 1,968 | 14% n = 1,398 | 13% n = 2,579 | 24% n = 1,938 |
aPZQ = praziquantel.
