Volume 6, Number 6—December 2000
Synopsis
Hemophagocytic Syndromes and Infection
David N. Fisman
Table
Clinical signs and laboratory abnormalities associated with hemophagocytic lymphohistiocytosis
| Clinical sign | % of patients affected | Reference |
|---|---|---|
| Fever* | 60-100 | 5,18-21 |
| Splenomegaly* | 35-100 | 5,19-21 |
| Hepatomegaly | 39-97 | 5,19-21 |
| Lymphadenopathy | 17-52 | 5,18-21 |
| Rash | 3-65 | 5,18-21 |
| Neurologic signs | 7-47 | 19,21 |
| Laboratory abnormality | % | Reference |
| Anemia* | 89-100 | 5,19,20 |
| Thrombocytopenia* | 82-100 | 5,19,20 |
| Neutropenia* | 58-87 | 5,19,21 |
| Hypertriglyceridemia* | 59-100 | 5,19,21 |
| Hypofibrinogenemia* | 19-85 | 5,19,21 |
| Hyperbilirubinemia | 74 | 19 |
*Proposed diagnostic criterion for HLH (2)
