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Volume 6, Number 6—December 2000

Synopsis

Hemophagocytic Syndromes and Infection

David N. FismanComments to Author 
Author affiliation: Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

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Table

Clinical signs and laboratory abnormalities associated with hemophagocytic lymphohistiocytosis

Clinical sign % of patients affected Reference
Fever* 60-100 5,18-21
Splenomegaly* 35-100 5,19-21
Hepatomegaly 39-97 5,19-21
Lymphadenopathy 17-52 5,18-21
Rash 3-65 5,18-21
Neurologic signs 7-47 19,21
Laboratory abnormality % Reference
Anemia* 89-100 5,19,20
Thrombocytopenia* 82-100 5,19,20
Neutropenia* 58-87 5,19,21
Hypertriglyceridemia* 59-100 5,19,21
Hypofibrinogenemia* 19-85 5,19,21
Hyperbilirubinemia 74 19

*Proposed diagnostic criterion for HLH (2)

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