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Volume 6, Number 6—December 2000

Research

Hantavirus Pulmonary Syndrome Associated with Monongahela Virus, Pennsylvania

Luther V. Rhodes*Comments to Author , Cinnia Huang†, Angela J. Sanchez§, Stuart T. Nichol§, Sherif R. Zaki§, Thomas G. Ksiazek§, J.G. Humphreys¶, James J. Freeman*, and Kenneth R. Knecht*
Author affiliations: *Lehigh Valley Hospital, Allentown, Pennsylvania, USA; †New York State Department of Health, Albany, New York, USA; §Centers for Disease Control and Prevention, Atlanta, Georgia, USA; ¶Indiana University of Pennsylvania, Indiana, Pennsylvania, USA

Main Article

Table 1

Laboratory Data

Complete blood count Patient 1 Patient 2
Date 3/10/97 3/12/97 3/13/97 11/13/97 11/14/97 11/15/97 11/16/97
Time (hrs) 2057 1443 0700 1100 1356 1856 0450 0400 0925
Leukocytes 4,300 4,800 12,100 10,900 4,400 5,100 8,000 11,100 15,700
Polymorphonuclear cells (%) 58 60 45 53 67 62 81 58 73
Bands (%) 3 23 34 27 0 9 N/Da 11 N/D
Immunoblasts 4 1 3 5 2 N/D N/D N/D N/D
Platelets 100,000 27,000 13,000 2,000 128,000 74,000 59,000
Hematocrit 45.9 47.0 55.5 44.0 47.4 46.4 48.2
Creatinine (mg/dL) 0.8 0.8 1.9 1.2 1.1 1.0

aN/D, not done.

Main Article

1Three fragments of the virus genome were amplified by nested polymerase chain reaction to allow generation of nucleotide (nt) sequences 393 nt in length for an S segment region encoding the N protein, 259 nt in length for an M segment region (M-G1) encoding the G1 protein, and 205 nt in length for an M segment region (M-G2) encoding the G2 protein (12). Sequence data were analyzed by using the Wisconsin GCG Package (version 9.1) software. Initial multiple sequence alignment was done with the GCG Pileup program, and phylogenetic analysis was performed by using the Phylogenetic Analysis Using Parsimony (and other methods) program (version 4.0) (20).

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