TY - JOUR AU - Guiyoule, Annie AU - Gerbaud, Guy AU - Buchrieser, Carmen AU - Galimand, Marc AU - Rahalison, Lila AU - Chanteau, Suzanne AU - Courvalin, Patrice AU - Carniel, Elisabeth T1 - Transferable Plasmid-Mediated Resistance to Streptomycin in Clinical Isolate of Yersinia pestis T2 - Emerging Infectious Disease journal PY - 2001 VL - 7 IS - 1 SP - 43 SN - 1080-6059 AB - Plasmid-mediated high-level resistance to multiple antibiotics was reported in a clinical isolate of Yersinia pestis in Madagascar in 1997. We describe a second Y. pestis strain with high-level resistance to streptomycin, isolated from a human case of bubonic plague in Madagascar. The resistance determinants were carried by a self-transferable plasmid that could conjugate at high frequencies to other Y. pestis isolates. The plasmid and the host bacterium were different from those previously associated with multiple-drug resistance, indicating that acquisition of resistance plasmids is occurring in this bacterial species. Emergence of resistance to streptomycin in Y. pestis represents a critical public health problem since this antibiotic is used as the first-line treatment against plague in many countries. KW - France KW - Madagascar DO - 10.3201/eid0701.700043 UR - https://wwwnc.cdc.gov/eid/article/7/1/70-0043_article ER - End of Reference