Volume 7, Number 1—February 2001
Active Bacterial Core Surveillance of the Emerging Infections Program Network
Active Bacterial Core surveillance (ABCs) is a collaboration between the Centers for Disease Control and Prevention and several state health departments and universities participating in the Emerging Infections Program Network. ABCs conducts population-based active surveillance, collects isolates, and performs studies of invasive disease caused by Streptococcus pneumoniae, group A and group B Streptococcus, Neisseria meningitidis, and Haemophilus influenzae for a population of 17 to 30 million. These pathogens caused an estimated 97,000 invasive cases, resulting in 10,000 deaths in the United States in 1998. Incidence rates of these pathogens are described. During 1998, 25% of invasive pneumococcal infections in ABCs areas were not susceptible to penicillin, and 13.3% were not susceptible to three classes of antibiotics. In 1998, early-onset group B streptococcal disease had declined by 65% over the previous 6 years. More information on ABCs is available at www.cdc.gov/ncidod/dbmd/abcs. ABCs specimens will soon be available to researchers through an archive.
Bacterial infections are prototypical emerging diseases (1), and their recent history challenges the premature view that the battle against infectious diseases had been won. In the last 25 years, disease caused by multidrug-resistant Streptococcus pneumoniae became established on several continents, reaching the United States by the 1990s (2–4), and fatal infections caused by S. pyogenes (group A Streptococcus), a problem of the 19th century (5), have returned in toxic and necrotic forms (6). By the 1970s, group B Streptococcus replaced gram-negative bacteria and Staphylococcus aureus as the leading cause of sepsis in newborns (7,8). Researchers tackled the public health challenge of developing vaccines to protect children against the major causes of bacterial meningitis: Haemophilus influenzae type b, S. pneumoniae, and Neisseria meningitidis (9,10). A critical step for response to microbial adaptation is establishing a reliable tracking system. We describe active, population-based surveillance for serious bacterial infections that was established by the Centers for Disease Control and Prevention (CDC) as part of its response to emerging infectious diseases (11,12).
Active Bacterial Core surveillance (ABCs) was designed to estimate the burden of community-acquired invasive bacterial infections that typically manifest as sepsis and meningitis. The system determines incidence and trends of these diseases in a multistate population and uses molecular and microbiologic methods to characterize the organisms causing infection. As prevention strategies against some pathogens are used routinely (9,13,14), ABCs evaluates their impact and identifies missed opportunities for their application. Established in four states in 1995, ABCs now operates within the eight states of the Emerging Infections Program (EIP) network, representing a population of more than 30 million and ascertaining cases from more than 600 clinical microbiology laboratories. A ninth EIP state, Colorado, initiated ABCs during 2000. ABCs currently focuses on surveillance and special studies related to five pathogens: S. pneumoniae, H. influenzae, N. meningitidis, group A Streptococcus (S. pyogenes), and group B Streptococcus (S. agalactiae).
ABCs' predecessor was the active surveillance program for invasive bacterial diseases established in 1988 (also sponsored by CDC), which evaluated the efficacy of H. influenzae type b vaccines in infants (15), identified dietary risk factors for sporadic listeriosis (16,17), and compared the cost-effectiveness of strategies for preventing group B streptococcal disease in newborns (18). ABCs has expanded the scope of targeted conditions to address additional emerging infections such as necrotizing fasciitis (the so-called flesh-eating disease) and streptococcal toxic-shock syndrome, both severe manifestations of disease caused by group A Streptococcus. ABCs also now monitors the emergence of drug resistance in the community-acquired pathogen S. pneumoniae. ABCs is one of three core activities conducted by EIPs; the others are FoodNet (19) and the Unexplained Critical Illness and Death Project (20). This article, a progress report of the first 5 years of the EIP network's ABCs project, identifies easily accessible resources from this system for public health and infectious disease constituencies.
In 1999, ABCs was conducted in Connecticut as well as in part or all of the following states: California, Georgia, Maryland, Minnesota, New York, Oregon, and Tennessee (Figure 1). (For certain pathogens, surveillance is conducted statewide in Georgia, Maryland, Minnesota, and Oregon). The total population under surveillance in 1998 ranged from approximately 17.4 million for S. pneumoniae to 30.4 million for N. meningitidis.
A case is defined as isolation of one of the five pathogens from a usually sterile site (e.g., blood, cerebrospinal fluid, pleural fluid) in a resident of one of the surveillance areas. Detailed methods of case-finding, data collection, and laboratory audits conducted within ABCs have been described (10,21). The key features are active ascertainment of cases by state-based surveillance officers, who make regular contact with microbiology or infection control practitioners in all clinical microbiology laboratories processing sterile site cultures for the surveillance area; collection of isolates of the specified pathogens for laboratory testing by ABCs personnel (Table 1); and semiannual audits of all participating laboratories to identify missed cases. Because the surveillance is population-based and cases identified by audits are included in the final database, ABCs data are used to monitor incidence of these diseases in a large, defined population. With the use of race- and age-adjustment, ABCs data also permit annual projections of the estimated incidence as well as the estimated number of cases and deaths occurring in the entire United States. For national projections, cases with unknown race are distributed by area, on the basis of reported race distribution for known cases within eight age categories. U.S. census data for counties under surveillance and natality data on live births are the source of denominators for incidence calculations; the most recent year's population data available with age and race information at the county level are used for rate calculations.
Core surveillance activities include collecting epidemiologic and clinical data and characterizing isolates in terms of antimicrobial susceptibility, serotype or serogroup, and subtyping. ABCs also conducts special studies that use the surveillance infrastructure but require collection of additional data by chart review, patient interviews, or analysis of ABCs data together with complementary data sources. ABCs uses the following indicators to monitor performance: sensitivity of >90% for active surveillance (based on total cases detected by surveillance and the laboratory audit); collection of >85% of isolates from cases; enrollment of 90% of eligible participants into special studies.
ABCs is overseen by a steering committee consisting of CDC and state EIP representatives as well as external advisors from public health, infectious disease, and microbiology fields. These parties convey views from key constituents and annually evaluate the need to add or substract pathogens for surveillance. In 1999, CDC's National Center for Infectious Diseases awarded $10.7 million through cooperative agreements to eight EIP states; approximately $2.5 million (23%) of these funds supported ABCs-related activities.
In 1998, 6,992 cases of invasive disease caused by the five pathogens were reported from the eight sites. The rates of invasive disease (per 100,000) ranged from 1.0 for N. meningitidis to 24.1 for S. pneumoniae (Table 2). An estimated 97,000 invasive infections and 10,000 deaths per year in the United States are due to S. pneumoniae, group A and B streptococci, H. influenzae, and N. meningitidis. Despite continued availability of effective antimicrobial agents for each pathogen, approximately 1 in 10 cases results in death (Table 2). Substantial geographic variation exists in the incidence of invasive infections caused by each pathogen (Table 2). Among invasive S. pneumoniae infections, the proportion caused by drug-resistant organisms was three times higher in some areas than others (4); 8.4% of invasive pneumococci from New York were fully resistant to penicillin (MIC >2.0), while 25.4% of isolates from Tennessee were penicillin resistant. No penicillin-nonsusceptible (intermediate or resistant) strains of group A or group B Streptococcus have been detected to date.
Recent temporal changes are most dramatic for invasive group B streptococcal disease among infants less than 1 week old (i.e., early-onset disease), which declined 65% from 1993 to 1998 (Figure 2), during a period when the incidence of disease in older infants and adults remained stable (22). Data from ABCs provide a reliable standard for evaluating alternative methods for surveillance of drug resistance in S. pneumoniae, including sentinel surveillance methods (4) and use of aggregate data from antibiograms from multiple hospitals (23). The recent emergence of serogroup Y meningococci, demonstrated by ABCs, suggests that vaccine companies should consider incorporating serogroup Y in new meningococcal vaccines. In addition, the diversity in the outer membrane proteins of serogroup B meningococcal strains suggests that vaccines against these proteins may not be efficient means of preventing endemic serogroup B meningococcal disease.
The population-based collections of isolates from ABCs are used to evaluate subtyping methods (24), identify genetic mechanisms of antimicrobial resistance, determine vaccine formulations (25,26), and assess capsular switching among organisms (for vaccines based on capsular types) (27,28). ABCs has identified population-based risk factors for disease in various age groups (Table 3). A case-control study of invasive pneumococcal disease in young children showed that attendance at day care was associated with a substantial attributable risk for disease (29). A similar study of invasive pneumococcal disease in 18- to 64-year-old adults who were not immunocompromised identified active and passive smoking, in addition to household contact with a child in day care, as independent risk factors for disease (30). Models of age- and serogroup- or serotype-specific rates of invasive meningococcal and pneumococcal disease in the ABCs population have compared the potential impact of diverse immunization strategies for meningococcal and combined meningococcal-pneumococcal vaccines on disease prevention (32). The increased risk for pneumonia death occurring several days after illness onset associated with antimicrobial-resistant strains of S. pneumoniae was demonstrated by using multistate clinical and epidemiologic data from ABCs (33).
ABCs provides participating state health departments active contact with all acute-care hospitals and reference microbiology laboratories in the surveillance area. This network provides an infrastructure for public health communication and education, as well as a network of key contacts available for response to new or emerging concerns. Periodic surveys of laboratories within ABCs determined the adequacy of methods used to detect group B Streptococcus from prenatal screening specimens (34), the computerization of clinical microbiology laboratories and readiness for electronic laboratory-based reporting, and the routine procedures used by ABCs laboratories to detect antimicrobial resistance among S. pneumoniae, S. aureus, and several other organisms (35). ABCs and other EIP personnel have provided assistance with multistate response efforts to determine the burden of Creutzfeldt-Jakob disease (36) and contributed to efforts to determine the rate of rotavirus vaccine-related intussusception (37). Further, the presence of ABCs personnel in state health departments and academic institutions has strengthened communication links required for accurate reporting and feedback.
Since publication of consensus guidelines for the prevention of group B streptococcal disease in newborns, ABCs assessed the implementation of prevention practices and identified opportunities for preventing more cases. ABCs showed that hospital obstetric programs' adoption of policies to prevent group B streptococcal infection increased significantly (38) and that hospitals that had adopted or revised a policy in 1996 had significantly fewer cases in 1997 (39). ABCs is also tracking the characteristics of newborn group B streptococcal cases that continue to occur despite prevention guidelines to determine whether these represent failures of intrapartum antibiotic prophylaxis or failure to offer such prophylaxis to mothers at risk. In several EIPs, pilot prevention programs are in place to identify efficient ways to reduce the incidence of disease caused by ABCs pathogens. These include a multifaceted program to reduce inappropriate antibiotic use in the Baltimore metropolitan area and efforts to promote pneumococcal polysaccharide vaccine in populations at high risk in Rochester, New York; Minneapolis-St. Paul, Minnesota; metropolitan Atlanta, Georgia; and Portland, Oregon. The Connecticut and Minnesota health departments conducted demonstration projects that integrated prevention of group B streptococcal disease into routine perinatal care, building on successes with hepatitis B perinatal prevention programs and contributing to reduction of perinatal HIV transmission (40,41).
Nearly 100,000 invasive infections and 10,000 deaths caused by ABCs pathogens occur annually in the United States. Because few states routinely collect data and isolates for all of these infections, ABCs helps monitor disease and evaluate prevention programs at the national level. ABCs has now developed robust estimates of the magnitude of disease and deaths attributable to the five invasive pathogens (Table 2). A number of future priorities have been identified that take advantage of the careful characterization of isolates associated with invasive infection. Licensure and introduction of a seven-valent conjugate vaccine against S. pneumoniae necessitate evaluation of the impact of this new prevention tool on target populations (Table 4). Of particular interest will be evaluating whether indirect effects similar to those seen with the Hib vaccine (42) occur. The large birth cohort under surveillance through ABCs and the longitudinal data on both early-onset cases and hospital policies for disease prevention offer the opportunity to compare the two alternative strategies for group B streptococcal prevention (screening-based vs. risk-based) through two studies during the next few years. ABCs will continue to contribute to tracking progress in Hib elimination, monitor for emergence of other serotypes of H. influenzae, and provide data on strain-specific disease (e.g., serotype, serogroup, outer membrane type). Such information is valuable for evaluating new vaccines for group B Streptococcus and serogroup B meningococcus. ABCs data will also be used to define clusters of invasive group A streptococcal disease and to model the impact of possible strategies and new formulations of pneumococcal vaccines targeted against pneumococcal pneumonia in adults (Figure 3) as well as vaccines targeted against invasive group A Streptococcus syndromes.
The molecular biology revolution and improved understanding of host-pathogen interactions offer great potential to advance knowledge about ABCs bacteria. Emerging antimicrobial resistance and other forms of pathogen adaptation (e.g., capsular switching) lend an urgency to such research. Specimens from invasive disease surveillance represent well-characterized, population-based collections with relevant clinical and demographic information. These provide a valuable resource for basic and applied research focused on issues as varied as new drug and vaccine development, evaluation of mechanisms of virulence and antimicrobial resistance, and genetic research. ABCs is planning to make these strains available to outside researchers and industry through a preserved collection. Such a specimen bank could provide a lasting legacy of the work of hundreds of infection control practitioners, clinical microbiology laboratories, and ABCs surveillance collaborators.
To ensure that ABCs' lessons learned within the EIP network reach other public health constituents, a number of efforts are under way. Additional details of the surveillance system and outreach materials are available at http://www.cdc.gov/ncidod/dbmd/abcs. Other educational materials are available at http://www.cdc.gov/ncidod/dbmd/gbs and at http://www.cdc.gov/ncidod/dbmd/antibioticresistance. For laboratories evaluating new strains of group A Streptococcus, genetic sequencing data of all strains described thus far is also available on the web. A similar site for meningococcal isolates is under development.
ABCs is a model of collaboration between public health and academia. The system provides reliable data that can be used to address critical public health concerns, improve understanding of emerging infections, and help prevent the consequences of these infections. While the past 5 years have helped quantify the magnitude of disease caused by these pathogens and document increasing antibiotic resistance in some of them, the future provides several challenges. To remain a vital component in the nation's efforts to prevent and control emerging infectious diseases, ABCs will need to incorporate surveillance and research tools of the 21st century, including electronic laboratory-based reporting, genotyping of pathogens, and improved communication to promote behavioral change and uptake of practice guidelines.
Dr. Schuchat is chief of the Respiratory Diseases Branch at the Centers for Disease Control and Prevention. Her research interests include group B streptococcal disease, evaluation of vaccines against meningitis and pneumonia, and prevention of perinatal infections.
We thank the National Center for Infectious Diseases Emerging Infections Program and infection control practitioners and clinical microbiologists who collaborate on ABCs. We also thank the following additional members of the ABCs team: California: Duc Vugia, Gretchen Rothrock, Pam Daily, Lisa Gelling; Connecticut: James Hadler, Matt Cartter, Pat Mshar, Craig Morin, Aaron Roome, Heather Linardos; Georgia: Paul Blake, David Stephens, Kathryn Arnold, Wendy Baughman, Katherine McCombs, Sabrina Burden, Patricia Martell-Cleary, Mathew Sattah; Maryland: Margaret Pass, Diane Dwyer; Minnesota: Ruth Lynfield, Catherine Lexau, Jean Rainbow, Karen White, Lori Triden, Brenda Sayler; New York: Perry Smith, Shelly Zansky, Barbara Damaske, Nancy Bennett, Glenda Smith, Nellie Dumas, Brian Sauders, Hwa Gan Chang; Oregon: Paul Cieslak, Linda Duke; Tennessee: Allen Craig, William Schaffner, Brenda Barnes, Carolyn Gilmore; CDC: Katherine Robinson, Chris Van Beneden, Cynthia Whitney, Nancy Rosenstein, Carolyn Wright, Kathleen Shutt, Melissa Berkowitz, Falgunee Parekh, Richard Facklam, Bernard Beall, John Elliott, and Tanja Popovic.
- Lederberg J, Shope RE, Oaks SCJ. Emerging infections: microbial threats to health in the United States. Washington: National Academy Press; 1992.
- Centers for Disease Control and Prevention. Defining the public health impact of drug-resistant Streptococcus pneumoniae: report of a working group. MMWR Morb Mortal Wkly Rep. 1996;45(No.RR-1):1–14.
- Klugman KP. Pneumococcal resistance to antibiotics. Clin Microbiol Rev. 1990;3:171–96.
- Centers for Disease Control and Prevention. Geographic variation in penicillin resistance in Streptococcus pneumoniae--selected sites, United States, 1997. MMWR Morb Mortal Wkly Rep. 1999;48:656–61.
- Charles D, Larsen B. Streptococcal puerperal sepsis and obstetric infections: a historical perspective. Rev Infect Dis. 1986;8:411–22.
- Schwartz B, Facklam RR, Breiman RF. Changing epidemiology of group A streptococcal infection in the USA. Lancet. 1990;336:1167–71.
- Freedman RA, Ingram DL, Gross I, Ehrenkranz PA, Warshaw JB, Baltimore RS. A half century of neonatal sepsis at Yale, 1928 to 1978. Am J Dis Child. 1981;135:140–4.
- McCracken GH. Group B streptococci: the new challenge in neonatal infections. J Pediatr. 1973;82:703–6.
- Centers for Disease Control and Prevention. Recommendations for use of Haemophilus influenzae b conjugate vaccines and a combined diphtheria, tetanus, pertussis and Haemophilus b vaccine. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep. 1993;42(RR-13):1–15.
- Schuchat A, Robinson K, Wenger JD, Harrison LH, Farley M, Reingold AL, Bacterial meningitis in the United States in 1995. N Engl J Med. 1997;337:970–6.
- Centers for Disease Control and Prevention. Addressing emerging infectious disease threats: a prevention strategy for the United States. Atlanta: Centers for Disease Control and Prevention; 1994.
- Centers for Disease Control and Prevention. Preventing emerging infectious diseases: a strategy for the 21st century. Atlanta: Centers for Disease Control and Prevention; 1998.
- Schuchat A, Whitney C, Zangwill K. Prevention of perinatal group B streptococcal disease: a public health perspective. MMWR Morb Mortal Wkly Rep. 1996;45(No. RR-7):1–24.
- Centers for Disease Control and Prevention. Prevention of pneumococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep. 1997;46(RR-8):1–24.
- Wenger JD, Pierce R, Deaver K, Plikaytis BD, Facklam RR, Broome CV. Efficacy of Haemophilus influenzae type b polysaccharide-diptheria toxoid conjugate vaccine in US children aged 18-59 months. Lancet. 1991;338:395–8.
- Schuchat A, Deaver K, Wenger JD, Plikaytis BD, Mascola L, Pinner RW, Role of foods in sporadic listeriosis. I: case-control study of dietary risk factors. JAMA. 1992;267:2041–5.
- Pinner RW, Schuchat A, Swaminathan B, Hayes PS, Deaver KA, Weaver RE, Role of foods in sporadic listeriosis. II: microbiologic and epidemiologic investigation. JAMA. 1992;267:2046–50.
- Mohle-Boetani J, Schuchat A, Plikaytis BD, Smith D, Broome CV. Comparison of prevention strategies for neonatal group B streptococcal infection: a population-based economic analysis. JAMA. 1993;270:1442–8.
- Centers for Disease Control and Prevention. The Foodborne Diseases Active Surveillance Network, 1996. MMWR Morb Mortal Wkly Rep. 1997;46:258–61.
- Perkins BA, Flood JM, Danila R, Holman RC, Reingold AL, Klug LA, Unexplained deaths due to possibly infectious causes in the United States: defining the problem and designing surveillance and laboratory approaches. Emerg Infect Dis. 1996;2:47–53.
- Zangwill KM, Schuchat A, Wenger JD. Group B streptococcal disease in the United States, 1990: report from a multistate active surveillance system. MMWR Morb Mortal Wkly Rep. 1992;41(SS-6):25–32.
- Schrag S, Zywicki S, Farley MM, Reingold AL, Harrison LH, Lefkowitz LB, Group B streptococcal disease in the era of intrapartum antibiotic prophylaxis, 1993-1998. N Engl J Med. 2000;342:15–20.
- Chin AE, Hedberg K, Cieslak PR, Cassidy M, Stefonek KR, Fleming DW. Tracking drug-resistant Streptococcus pneumoniae in Oregon: an alternative surveillance method. Emerg Infect Dis. 1999; 5.
- Beall B, Facklam R, Thompson T. Sequencing the emm-specific PCR products for routine and accurate typing of group A streptococci. J Clin Microbiol. 1996;34:953–8.
- Harrison LH, Dwyer DM, Johnson JA. Emergence of serotype V group B streptococcal infection among infants and adults. J Infect Dis. 1995;171:513.
- Blumberg HM, Stephens DS, Modansky M, Erwin M, Elliott J, Facklam R, Invasive group B streptococcal disease: the emergence of serotype V. J Infect Dis. 1996;173:365–73.
- Swartley JS, Marfin AA, Edupuganti S, Liu LJ, Cieslak P, Perkins B, Capsule switching of Neisseria meningitidis. Proc Natl Acad Sci U S A. 1997;94:271–6.
- Gherardi G, Whitney C, Facklam R, Beall B. Major related sets of antibiotic-resistant pneumococci in the United States as determined by pulsed-field gel electrophoresis and pbp1a-pbp2b-pbp2x-dhf restriction profiles. J Infect Dis. 2000;181:216–29.
- Levine OS, Farley MM, Harrison LH, Lefkowitz L, McGeer A, Schwartz B. Risk factors for invasive pneumococcal disease in children: a population-based case-control study in North America. Pediatrics. 1999;103:e28.
- Nuorti JP, Butler JC, Farley MM, Harrison LH, McGeer A, Kolczak MS, Cigarette smoking and invasive pneumococcal disease. N Engl J Med. 2000;342:681–9.
- Fischer M, Harrison L, Farley M, Lefkowitz L, McGeer A, Schuchat A, Risk factors for sporadic meningococcal disease in North America. Philadelphia: Infectious Diseases Society of America; 2000.
- Lingappa J, Zell E, Rosenstein N, Schuchat A, Perkins BA. Active Bacterial Core surveillance. Impact of vaccination strategies using meningococcal conjugate vaccines in the United States. Philadelphia: Infectious Disease Society of America; 1999.
- Feikin DR, Schuchat A, Kolczak M, Barrett NL, Harrison LH, Lefkowitz L, Mortality for invasive pneumococcal pneumonia in the era of antibiotic resistance, 1995-1997. Am J Public Health. 2000;90:223–9.
- Centers for Disease Control and Prevention. Laboratory practices for prenatal group B streptococcal screening and reporting--Connecticut, Georgia, and Minnesota, 1997-1998. MMWR Morb Mortal Wkly Rep. 1999;48:426–8.
- Centers for Disease Control and Prevention. Laboratory capacity to detect antimicrobial resistance. MMWR Morb Mortal Wkly Rep. 2000;48:1167–71.
- Centers for Disease Control and Prevention. Surveillance for Creutzfeldt-Jakob Disease--United States. MMWR Morb Mortal Wkly Rep. 1996;45:665–8.
- Centers for Disease Control and Prevention. Intussusception among recipients of rotavirus vaccine--United States, 1998-1999. MMWR Morb Mortal Wkly Rep. 1999;48:577–81.
- Centers for Disease Control and Prevention. Adoption of hospital policies for prevention of perinatal group B streptococcal disease--United States, 1997. MMWR Morb Mortal Wkly Rep. 1998;47:665–70.
- Factor SH, Whitney CG, Zywicki S, Schuchat A. the ABC Surveillance Team. Effects of hospital policies on the 1996 Group B streptococcal consensus guidelines. Obstet Gynecol. 2000;95:377–82.
- Roome A, Carley K, Melchreit R, Foye G, Hadler J. Testing pregnant women for HIV. A survey of obstetricians and review of patient prenatal/obstetric medical records--Connecticut 1996-1997. Conn Med. 1999;63:541.
- Lynfield R, Rubin M, White K, Schuchat A, Moore K, Osterholm M, Prenatal HIV screening practices in Minnesota. Philadelphia: Infectious Diseases Society of America; 1999.
- Adams WG, Deaver KA, Cochi SL, Plikaytis BD, Zell ER, Broome CV, Decline of childhood Haemophilus influenzae type b disease in the Hib vaccine era. JAMA. 1993;269:221–6.
- Figure 1. States included in Active Bacterial Core surveillance in 1999 (shaded). Surveillance for all pathogens was conducted statewide in Connecticut but in selected counties only for some or all pathogens...
- Figure 2. Invasive group B streptococcal disease in infants less than 1 week of age per 1,000 live births and in adults >65 years of age per 100,000 population, Active...
- Figure 3. Age-specific incidence (per 100,000) and case-fatality ratio (percent) of invasive pneumococcal disease, Active Bacterial Core surveillance, 1998.
- Table 1. Laboratory characterization of isolates collected as part of the Active Bacterial Core surveillance program
- Table 2. Incidence, case-fatality ratio, projected U.S. cases and deaths, and proportion nonsusceptible to penicillin of invasive disease identified in the Active Bacterial Core surveillance (ABCs), 1998
- Table 3. Population-based risk factors for invasive disease, identified by Active Bacterial Core surveillance
- Table 4. Future priorities for Active Bacterial Core surveillance (ABCs) project
Suggested citation for this article: Anne Schuchat, Tami Hilger, Elizabeth Zell, Monica M. Farley, Arthur Reingold, Lee Harrison, Lewis Lefkowitz, Richard Danila, Karen Stefonek, Xavier de Lamballerie. Active Bacterial Core Surveillance of the Emerging Infections Program Network. Emerg Infect Dis [serial on the Internet]. 2001 Jan-Feb [date cited] http://wwwnc.cdc.gov/eid/article/7/1/70-0092
Please use the form below to submit correspondence to the authors or contact them at the following address:
Anne Schuchat, Centers for Disease Control and Prevention, Mailstop C23, 1600 Clifton Rd., Atlanta, GA 30333, USA; fax: 404-639-3970
Comment submitted successfully, thank you for your feedback.
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
- Page created: March 16, 2011
- Page last updated: March 16, 2011
- Page last reviewed: March 16, 2011
- Centers for Disease Control and Prevention,
National Center for Emerging and Zoonotic Infectious Diseases (NCEZID)
Office of the Director (OD)