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Volume 7, Number 3—June 2001

Synopsis

Cryptococcus neoformans Infection in Organ Transplant Recipients: Variables Influencing Clinical Characteristics and Outcome

Shahid Husain, Marilyn M. Wagener, and Nina SinghComments to Author 
Author affiliations: Veterans Affairs Medical Center and University of Pittsburgh, Thomas E. Starzl Transplantation Institute, Pittsburgh, Pennsylvania, USA

Main Article

Table 1

Variables associated with early and late-onset Cryptococcus neoformans infection in organ transplant recipients

Variable (no. of patients for whom data available) Early onset (within 12 months) (%) Late onset (>12 months) (%) p value
Age (mean) 42.2 yrs 44.3 yrs NSa
Type of transplant 0.001
Liver (20) 75 25
Kidney (54) 28 72
Heart (9) 33 67
Lung (2) 100 0
Cytomegalovirus (CMV) infection (2) 50 50 NS
No CMV infection (6) 67 33
Prior rejection (16) 50 50 NS
No prior rejection (45) 36 64
U.S. region 0.004b
Northeast (24) 67 33
West (19) 32 68
Midwest (9) 22 78
South (20) 40 60
Other countries
Europe (7) 28 71
Asia (3) 33 67
Site involved
Lung (26) 42 58 NS
Central nervous system (57) 40 60
Skin/osteoarticular (23) 30 70
Death rate (84) 34 41

aNS = not significant, p >0.05.
bNortheastern United States versus all other regions.

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