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Volume 7, Number 3—June 2001

Synopsis

Cryptococcus neoformans Infection in Organ Transplant Recipients: Variables Influencing Clinical Characteristics and Outcome

Shahid Husain, Marilyn M. Wagener, and Nina SinghComments to Author 
Author affiliations: Veterans Affairs Medical Center and University of Pittsburgh, Thomas E. Starzl Transplantation Institute, Pittsburgh, Pennsylvania, USA

Main Article

Table 3

Variables associated with death in organ transplant recipients with Cryptococcus neoformans infection

Variable (no. of patients for whom data available) Death (%) Survival (%) p value
Age (mean) 43.6 yrs 43.4 yrs NSa
Prior rejection (17) 35 65 NS
No rejection (50) 28 72
Rejection within 6 months of onset of cryptococcosis (3) 33 67 NS
Increased immunosuppression (11) 46 54 NS
Fever (39) 31 69 NS
No fever (21) 33 67
Renal failure (37) 43 57 0.005
No renal failure (18) 6 94
Mental status 0.03
Abnormal (22) 54 45
Normal (53) 28 72
Treatment NS (0.16)
AmBb (52)
AmB + 5 FCc (77) 48 52
Fluconazole (14) 38 62
Site involved 21 79 0.04d
Central nervous system (101) 49 51
Pulmonary (32) 22 78
Skin/osteoarticular (28) 21 79
Type of transplant NS
Liver (20) 40 60
Kidney (139) 41 59
Heart (10) 60 40
Lung (3) 33 67

aNS = not significant, p >0.05.
bAmB = amphotericin B deoxycholate.
cFC = flucytosine. Dp value represents the difference for CNS versus other sites.

Main Article

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