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Volume 7, Number 3—June 2001

Synopsis

Cryptococcus neoformans Infection in Organ Transplant Recipients: Variables Influencing Clinical Characteristics and Outcome

Shahid Husain, Marilyn M. Wagener, and Nina SinghComments to Author 
Author affiliations: Veterans Affairs Medical Center and University of Pittsburgh, Thomas E. Starzl Transplantation Institute, Pittsburgh, Pennsylvania, USA

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Table 4

Variables associated with death in patients with central nervous system Cryptococcus neoformans infection

 Variable (no. of patients for whom data available) Death (%) Survival (%) p value
Age (mean) 40.6 yrs 42.4 yrs NSa
Fever (29) 34 (10/29) 66 (10/29) NS
No fever (7) 43 (3/7) 57 (4/7)
Headache (20) 25 (5/20) 75 (15/20) NS (.09)
No headache (21) 52 (11/21) 48 (10/21)
Abnormal mental status (20) 55 (11/20) 45 (9/20) NS
Normal mental status (26) 31 (8/26) 69 (18/26)
White blood cell >20/mm3 (20) 40 (8/20) 60 (12/20) NS
White blood cell <20/mm3 (13) 62 (8/13) 38 (5/13)
Cryptococcal antigen titer >1,024 (10) 20 (2/10) 80 (8/10) NS
Cryptococcal antigen titer <1,024 (17) 35 (6/17) 65 (11/17)
Positive blood culture (8) 13 (1/8) 87 (7/8) NS
Negative blood culture (16) 50 (8/16) 50 (8/16)
Renal failure (22) 54 (12/22) 46 (10/22) .011
No renal failure (12) 8 (1/12) 92 (11/12)
Therapy NS
AmBb alone (55) 47 (26/55) 53 (29/55)
AmB + 5 FCc (32) 50 (16/32) 50 (16/32)
Fluconazole (5) 40 (2/5) 60 (3/5)

aNS = not significant, p >0.05.
bAmB = Amphotericin B deoxycholate.
cFC = flucytosine.

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