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Volume 7, Number 4—August 2001
THEME ISSUE
West Nile Virus
West Nile Virus

West Nile Encephalitis in Israel, 1999: The New York Connection

Michael Giladi*Comments to Author , Einat Metzkor-Cotter*, Denise A. Martin*, Yardena Siegman-Igra*, Amos D. Korczyn*, Raffaele Rosso*, Stephen A. Berger*, Grant L. Campbell†, and Robert S. Lanciotti†
Author affiliations: *Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; †Centers for Disease Control and Prevention, Fort Collins, Colorado, USA

Main Article

Table 1

Antibodies to West Nile virus and clinically related flaviviruses in two encephalitis cases, Tel Aviv, 1999

Serum #1 Serum #2 CSF #1 CSF #2
Case 1
Days after onset 9 35 3 14
Antigen IgMa IgGa PRNTb IgM IgG PRNT IgM IgM
WN 13.8 1 10 13.7 3.6 640 0.9 21.6
Den 1-4 2.3 1.2 <10 2.6 1.7 <10 1 1.7
CHIK 0.9 1.2 0.9 1.2 1.2 1
SIN 1 1.2 1.1 1.2 1.1 1.1
POW/TBE 1 1.1 1.2 1.8 0.9 0.8
JE 2.8 0.8 <5 6.2 0.8 20 1.5 1.7
Case 2
Days after onset 14 NA 7 NA
Antigen IgM IgG PRNT IgM
WN 13.5 3.1 80 25.3
Den 1-4 1.7 1.3 1.4
CHIK 1 1.4 0.9
SIN 1.3 1.4 0.9
POW/TBE 1.1 1.4 1
JE 2.5 0.8 5 2.1

CSF = cerebrospinal fluid; CHIK, Chikungunya virus; Den 1-4 = dengue virus (types 1-4); JE = Japanese encephalitis virus; NA = not available; POW/TBE = Powassan virus tick-borne encephalitis virus; PRNT = plaque-reduction neutralization test; SIN = Sindbis virus; WN = West Nile virus.
aImmunoglobulin M (IgM) and IgG antibody levels were determined by enzyme immunoassay. Results are expressed as positive-negative absorbance ratios (P/Ns), determined by dividing the average optical density of the test sera by the average optical density measured for the negative control sera, with values >3.0 considered to be positive.
bResults of the PRNT are expressed as reciprocal antibody titers, with values 20 considered to be positive.

Main Article

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