Adaptation of Bordetella pertussis to Vaccination: A Cause for Its Reemergence?
Figure 2. . Changes in the population structure of B. pertussis in The Netherlands as determined by IS1002-based DNA fingerprinting. Strains isolated from Dutch patients from 1949 to 1996 were stratified in periods of 5 to 8 years. The frequency of fingerprint types (Ft) in each period was determined and is displayed by colored bars. Genotypic diversity was calculated according to Nei, using fingerprint data (11). Adapted from (10).