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Volume 8, Number 10—October 2002
THEME ISSUE
Bioterrorism-related Anthrax

Bioterrorism-related Anthrax

Antimicrobial Postexposure Prophylaxis for Anthrax: Adverse Events and Adherence

Colin W. Shepard*Comments to Author , Montse Soriano-Gabarro*, Elizabeth R. Zell*, James Hayslett*, Susan Lukacs*, Susan Goldstein*, Stephanie Factor*†, Joshua Jones*, Renee Ridzon*, Ian Williams*, Nancy Rosenstein*, and the CDC Adverse Events Working Group
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †New York Academy of Medicine, New York, New York, USA;

Main Article

Table 6

Factors associated with nonadherence, multivariable analysis, post 60-day data, 2001–2002a

Variable Participants reporting non-adherence (1–59 days of antimicrobial prophylaxis) among persons taking at least one dose
Florida
(n=744)
OR (95% CI) New Jersey
(n=1,028)
OR (95% CI) Hart Senate Building
(n=472)
OR (95% CI) Brentwood facility
(n=1,619)
OR (95% CI) New York City
(n=882)
OR (95% CI) Connecticut
(n=598)
OR (95% CI)
Gender
Male 1.00 (0.71, 1.41) 0.56 (0.42, 0.76) 0.92 (0.61, 1.38) 0.90 (0.71, 1.13) 0.57 (0.41, 0.79) 0.99 (0.67, 1.46)
Female Referent Referent Referent Referent Referent Referent
Age
17–39 yr Referent Referent Referent Referent Referent Referent
40–64 yr 0.51 (0.36, 0.72) 0.54 (0.40, 0.73) 0.82 (0.53, 1.28) 0.42 (0.32, 0.56) 0.61 (0.41, 0.90) 0.96 (0.64, 1.44)
>65 yr 0.73 (0.28, 1.89) 0.51 (0.23, 1.12) n/a 0.49 (0.24, 1.02) 0.17 (0.08, 0.39) 0.21 (0.07, 0.65)
Race
African-American 1.80 (0.66, 4.92) 1.47 (1.06, 2.05) 1.87 (1.08, 3.25) 0.90 (0.63, 1.28) 1.08 (0.76, 1.52) 1.39 (0.86, 2.24)
All others Referent Referent Referent Referent Referent Referent
Ethnicity
Hispanic 0.78 (0.47, 1.29) 2.42 (1.21, 4.86) 1.58 (0.42, 6.01) 0.62 (0.23, 1.69) 1.57 (1.03, 2.39) 1.42 (0.68, 2.93)
Non-Hispanic Referent Referent Referent Referent Referent Referent
Adverse events
Yes 2.23 (1.61, 3.09) 1.08 (0.82, 1.44) 1.07 (0.71, 1.62) 0.98 (0.77, 1.24) 1.58 (1.16, 2.16) 1.32 (0.92, 1.90)
No Referent Referent Referent Referent Referent Referent
IND enrollment
Yes 0.36 (0.21, 0.64) 0.27 (0.19, 0.38) 0.09 (0.04, 0.24) 0.28 (0.22, 0.36) 0.33 (0.21, 0.52) 0.64 (0.39, 1.05)
No Referent Referent Referent Referent Referent Referent

aOR, odds ratio; CI, confidence interval; IND, investigational new drug.

Main Article

1 Michael Bales, Judith Cobb, Leigh Farrington, Alicia Fry, Emily Zielinski Gutierrez, Renee Joskow, Pavani Kalluri, Aileen Kenneson, Savita Kumar, Jill Morris, Melanie F. Myers, Robert Newman, Chima Ohuabunwo, John T. Redd, Sharon Roy, Stephanie Schrag, Andi Shane, Reina Turcios, Kevin Winthrop, and Mitchell Wolfe.

2 Paul Abomonte, Denise Allen,Veronica Alvarez, Alina Alonso, Mary Kate Appicelli, Mike Beach, Beth Bell, Susan Blank, Amy Bloom, Jennifer Brooks, Jane Buckner, Jim Buehler, Heather Burke, Louise Causer, Eleanor Cawthorne, Marty Cetron, Shadi Chamany, Charles Chamberlain, Isa Chinea, Bruce Clemons, Gary Cobb, Pat Cook, Margaret Cooke, Sara Critchley, Donita Croft, Colleen Crowley, Valerie J.Curry, Nick Deluca, Catherine Dentinger, Bob DiGregorio, William Duck, Peter Dull, Jeff Efird, Evelyn Finch, Bridgette Finkelstein, Robert Fireall, Mike Fraser, Cindy Friedman, Kathi Gallagher, Julie Gerberding, Dawn Gnesda, Missy Goveia, Carolyn Greene, Kevin Griffith, Rana Hajjeh, Jennifer Hamborsky, Darryl Hardge, Daniel John Hewett, Kelly Holton, Mariaelena Jefferds, Greg Jones, Jim Jones, Sean Kaufmann, Michael Keith, Jonathan King, Linda Koenig, Lara Lamprecht, Kayla Laserson, Marci Layton, Suzanne Lebovit, Chang Lee, Norman Lee, Steven W. Lenhart, Mark Long, Jean Malecki, Greg Martin, Thomas Matte, Veronica McCant, Peter McElroy, Shawn McMahon, Theodies Mitchell, Juliette Morgan, Robin Moseley, Tim Morris, Dianne Murphy, Joyce Neale, Stephanie Noviello, John Painter, Margaret Patterson, Lisa Pealer, Cindy Pecoraro, Bradley Perkins, Bobbie Person, Joe Perz, Lyle Petersen, Bob Pinner, Gabriel Ponce De Leon, Pratima Raghunathan, Jennita Reefhuis, Julia Rhodes, Taraz Samandari, Anne Schuchat, James Sejvar, Curt Senft, Douglas Shaffer, Tanya Sharpe, Arlene Shaw, Wrenn Slocum, Julia Smith, John Stamper, Stefanie Steele, Jennifer Stevenson, David Swerdlow, Tina Tan, Kathryn Teates, Alison Tepper, Peg Tipple, Beth Tohill, Marc Traeger, Scott Tulloch, Reuben Varghese, Wanda Walton, Dana White, Sara Whitehead, Steve Wiersma, Holly Williams, Jennifer Williams, Leigh Winston, Heather Wurtzel, and Weigong Zhou.

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