Volume 8, Number 11—November 2002
Genomewide Pattern of Synonymous Nucleotide Substitution in Two Complete Genomes of Mycobacterium tuberculosis
|Reference||No. loci||Synomymous substitutions/site/yr||Divergence time (H37Rv and CDC1551)|
|11||67||4.7 ± 0.2 X 10-9||34,900 ± 2,300 b (33,500–36,400) c|
|12||128||4.4 X 10-9||37,300 ± 2,500 b|
aBased on synonymous substitutions between Escherichia coli and Salmonella typhimurium, assumed to have diverged 100 million years ago (13,14).
bEstimates are shown ± standard error, based on standard error of mean pS.
cRange based on standard error of rate estimate.
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