Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

Volume 8, Number 11—November 2002

Dispatch

Genomewide Pattern of Synonymous Nucleotide Substitution in Two Complete Genomes of Mycobacterium tuberculosis

Austin L. Hughes*Comments to Author , Robert Friedman*, and Megan Murray†
Author affiliations: *University of South Carolina, Columbia, South Carolina, USA; †Harvard School of Public Health, Boston, Massachusetts, USA;

Main Article

Table 1

Estimatesa of the divergence time of the H37Rv and CDC1551 genotypes of Mycobacterium tuberculosis

Reference No. loci Synomymous substitutions/site/yr Divergence time (H37Rv and CDC1551)
11 67 4.7 ± 0.2 X 10-9 34,900 ± 2,300 b (33,500–36,400) c
12 128 4.4 X 10-9 37,300 ± 2,500 b

aBased on synonymous substitutions between Escherichia coli and Salmonella typhimurium, assumed to have diverged 100 million years ago (13,14).
bEstimates are shown ± standard error, based on standard error of mean pS.
cRange based on standard error of rate estimate.

Main Article

TOP