Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

Volume 8, Number 11—November 2002

Dispatch

Genomewide Pattern of Synonymous Nucleotide Substitution in Two Complete Genomes of Mycobacterium tuberculosis

Austin L. Hughes*Comments to Author , Robert Friedman*, and Megan Murray†
Author affiliations: *University of South Carolina, Columbia, South Carolina, USA; †Harvard School of Public Health, Boston, Massachusetts, USA;

Main Article

Table 2

Proteins for which the nearest homologous comparison between the H37Rv and CDC1551 genotypes of Mycobacterium tuberculosis has a high pS value (Group B)

Accession nos. Protein function pS pN
Probable differential deletion
NP_216309, NP_335079 unknown 0.0470 0.0000
NP_215713, NP_335504 unknown 0.0628 0.0043
NP_216319, NP_336310 PE repeat family 0.0115 0.0094
NP_215965, NP_335949 PE repeat family 0.0448 0.0185
Possible horizontal gene transfer
NP_214910, NP_334815 unknown 0.0226 0.0105
NP_216104, NP_336077 unknown 0.0265 0.0084
NP_216281, NP_336535 unknown 0.0210 0.0161
NP_215835, NP_335809 adenylate cyclase 0.0229 0.0068
NP_216564, NP_336573 polyketide synthase 0.0093 0.0036
NP_217029, NP_337080 unknown 0.0148 0.0156
NP_216862, NP_335679 unknown 0.0313 0.0000
Mean ± S.E. 0.0286 ± 0.0050 0.0085 ±
0.0019a

aPaired sample t-test of the hypothesis that pS = pN , p<0.01. The quantities pS and pN are the proportion of nucleotide difference per synonymous site and per nonsynonymous site, respectively.

Main Article

TOP