National Tuberculosis Genotyping and Surveillance Network: Analysis of the Genotype Database
Figure 7. Motifs used to assign spoligotype patterns to spoligotype families. Each spoligotype was analyzed for the bovis (16), africanum (17), East-African-Indian (EA-I) (13,18), X (13), Latin American-Mediterranean 1 and 2 (13,18), and Haarlem a and b spoligotype motifs (10). Each motif definition was modified from the original references to ensure that motifs were not identified in a spoligotype pattern due to an unrelated deletion at the spacers of interest; each of the motif-defining absent spacers must be flanked on both sides by the adjacent spacer. The 43 spacers in the spoligotype pattern are classified with symbols: X: spacer must be present; 0: spacer must be absent; -: spacer may or may not be present; spacers in shaded boxes: at least one of the spacers in the box must be present.