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Volume 8, Number 11—November 2002
THEME ISSUE
Tuberculosis Genotyping

Tuberculosis Genotyping Network, United States

DNA Fingerprinting of Mycobacterium tuberculosis Isolates from Epidemiologically Linked Case Pairs

Diane E. Bennett*Comments to Author , Ida M. Onorato*, Barbara A. Ellis*, Jack T. Crawford*, Barbara Schable*, Robert Byers*, J. Steve Kammerer*, and Christopher R. Braden*
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA;

Main Article

Table 2

Univariate analysis of factors associated with transmission unconfirmed by DNA fingerprinting in tuberculosis case pairs identified in contact investigations in seven sites, 1996–2000

Variable Transmission unconfirmed (%) (n=156) Transmission confirmed (%) (n=382) Odds ratio
(95% confidence intervals) p valuea
Relationship between persons in case pairs
Shared household 80 (51) 180 (47) 1.2 (0.8 to 1.7) NS
Friends/social 55 (35) 156 (41) 0.8 (0.5 to 1.2) NS
Shared workplace 11 (7) 12 (3) 2.3 (1.1 to 5.4) 0.04
Other 10 (6) 34 (9) 1.0 (0.6 to 1.5) NS
Characteristics of source cases
Sputum smear-negative 56 (36) 73 (19) 2.4 (1.6 to 3.6) <0.0001
Cavitary disease 64 (41) 197 (52) 0.7 (0.5 to 1.0) NS
Characteristics of secondary cases
Foreign-born 73 (47) 60 (16) 4.7 (3.1 to 7.2) <0.0001
Previous tuberculosis 5 (3.0) 12 (3.0) 1.1 (0.4 to 3.7) NS
<15 yrs 8 (5) 65 (17) 0.4 (0.2 to 0.8) 0.007
>65 yrs 16 (11) 21 (6) 1.8 (0.9 to 3.6) NS
HIV positive 13 (8) 33 (9) 1.0 (0.5 to 1.9) NS
Characteristics of case pairs
Both white 14 (9) 42 (11) 0.5 (0.4 to 1.5) NS
Both black 62 (40) 221 (58) 0.5 (0.3 to 0.7) 0.005
Both Hispanic 21 (14) 46 (12) 1.1 (0.7 to 2.0) NS
Both Asian or Pacific Islander 35 (22) 29 (8) 3.5 (2.1 to 6.0) <0.0001
Racial discrepancy 24 (15) 40 (11) 1.2 (0.9 to 1.4) NS
Age difference >10 yrs 88 (56) 198 (52) 1.2 (0.8 to 1.7) NS

aNS, not significant.

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