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Volume 8, Number 11—November 2002
THEME ISSUE
Tuberculosis Genotyping

Tuberculosis Genotyping Network, United States

Use of DNA Fingerprinting To Investigate a Multiyear, Multistate Tuberculosis Outbreak

Peter D. McElroy*Comments to Author , Timothy R. Sterling†, Cynthia R. Driver‡, Barry Kreiswirth§, Charles L. Woodley*, Wendy A. Cronin¶, Darryl X. Hardge*†, Kenneth L. Shilkret#, and Renee Ridzon1*
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †Baltimore City Health Department, Baltimore, Maryland, USA; ‡New York City Department of Health, New York City, New York, USA; §Public Health Research Institute, New York City, New York, USA; ¶Maryland State Department of Health and Mental Hygiene, Baltimore, Maryland, USA; #New Jersey Department of Health and Senior Services, Trenton, New Jersey, USA;

Main Article

Table 1

Clinical characteristics of tuberculosis outbreak patients, New Jersey, New York City, Baltimore, and Maryland, 1995–2001

Characteristic New Jersey
n=5 New York City
n=10 Baltimore
n=18 Maryland
n=6 Total
n=39 (%)
Culture-positive 4 10 17 5 36 (92)
Sputum smear–positive 1 4 9 3 17 (44)
Disease site
Pulmonary only 2 5 11 4 22 (56)
Exrapulmonary only 0 2 4 2 8 (21)
Pulmonary-extrapulmonary 3 3 3 0 9 (23)
Cavitary disease 0 0 2 1 3 (8)
HIV status
Positive 2 7 11 1 21 (54)
Unknown 1 0 1 1 3 (8)
Deceaseda 2 2 1 1 6 (15)

aFour of six patients died within 3 months of their TB diagnosis.

Main Article

1 PDM, TRS, CRD, BK, CLW, WAC, DXH, KLS, and RR were involved in the conception and design of various phases (epidemiologic and laboratory methods) of this investigation. All coauthors were responsible for collection of either epidemiologic or molecular genotyping data. Analysis and interpretation of the data were primarily performed by PDM, TRS, and RR. All coauthors participated in preparation and critical review of the manuscript.

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