TY - JOUR AU - Halstead, Scott B. AU - Lan, Nguyen Trong AU - Myint, Thein Thein AU - Shwe, Than Nu AU - Nisalak, Ananda AU - Kalyanarooj, Siripen AU - Nimmannitya, Suchitra AU - Soegijanto, Soegeng AU - Vaughn, David W. AU - Endy, Timothy P. T1 - Dengue Hemorrhagic Fever in Infants: Research Opportunities Ignored T2 - Emerging Infectious Disease journal PY - 2002 VL - 8 IS - 12 SP - 1474 SN - 1080-6059 AB - The age distribution of cases of dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) in infants under the age of 1 year are reported from Bangkok, Thailand, and for the first time for Ho Chi Minh City, Vietnam; Yangon, Myanmar; and Surabaya, Indonesia. The four dengue viruses were isolated from Thai infants, all of whom were having a primary dengue infection. Progress studying the immunologically distinct infant DHF/DSS has been limited; most contemporary research has centered on DHF/DSS accompanying secondary dengue infections. In designing research results obtained in studies on a congruent animal model, feline infectious peritonitis virus (FIPV) infections of kittens born to FIPV-immune queens should be considered. Research challenges presented by infant DHF/DSS are discussed. KW - dengue KW - dengue virus KW - viral hemorrhagic fevers KW - flavivirus KW - immunology KW - epidemiology KW - pathogenesis KW - infant KW - infectious diseases KW - feline infectious peritonitis virus KW - Vietnam KW - Thailand KW - Indonesia KW - Myanmar DO - 10.3201/eid0812.020170 UR - https://wwwnc.cdc.gov/eid/article/8/12/02-0170_article ER - End of Reference