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Volume 8, Number 12—December 2002

Research

Efficacy of Killed Virus Vaccine, Live Attenuated Chimeric Virus Vaccine, and Passive Immunization for Prevention of West Nile virus Encephalitis in Hamster Model

Robert B. Tesh*Comments to Author , Juan Arroyo†, Amelia P.A. Travassos da Rosa*, Hilda Guzman*, Shu-Yuan Xiao*, and Thomas P. Monath†
Author affiliations: *University of Texas Medical Branch, Galveston, Texas, USA; †Acambis, Inc., Cambridge, Massachusetts, USA;

Main Article

Table 2

WNV antibody response of hamsters after immunization with WNV killed virus vaccine (Fort Dodge) and challenge with the NY385-99 strain of WNVa,b

Animal no. HI antibody titer CF antibody titer PRN antibody titerc
32 days after Ft. Dodge vaccine
H-8440 1:40 1:40 1:20
H-8441 0d 0 <1:10
H-8442 1:20 1:40 <1:10
H-8443 1:40 1:40 1:20
H-8445 1:40 1:40 1:20
H-8446 1:20 1:20 1:40
H-8447 1:20 1:20 <1:10
H-8448 1:20 1:20 <1:10
H-8449 1:40 1:20 1:10
6 days after challenge with WNV
H-8440 1:80 1:80 ND
H-8441 1:320 1:160 ND
H-8442 1:40 1:40 ND
H-8443 1:40 1:40 ND
H-8445 1:320 1:160 ND
H-8446 1:80 1:40 ND
H-8447 1:320 1:160 ND
H-8448
1:160
1:80
ND
H-8449 1:160 1:40 ND

aWNV, West Nile virus; HI, hemagglutination inhibition; CF, complement fixation; PRN, plaque reduction neutralization; ND, not done.
b104.0 50% tissue culture infective dose50 given intraperitoneally.
cHighest serum dilution producing >90% plaque inhibition.
d0 = <1:20.

Main Article

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