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Volume 8, Number 12—December 2002

Research

Efficacy of Killed Virus Vaccine, Live Attenuated Chimeric Virus Vaccine, and Passive Immunization for Prevention of West Nile virus Encephalitis in Hamster Model

Robert B. Tesh*Comments to Author , Juan Arroyo†, Amelia P.A. Travassos da Rosa*, Hilda Guzman*, Shu-Yuan Xiao*, and Thomas P. Monath†
Author affiliations: *University of Texas Medical Branch, Galveston, Texas, USA; †Acambis, Inc., Cambridge, Massachusetts, USA;

Main Article

Table 4

Antibody response of adult golden hamsters to intramuscular inoculation of 1.8 X 106 of ChimeriVax–WNV and subsequent challenge with WNV (104.0 TCID50 given intraperitoneally)a

Animal no.
HI antibody titer
CF antibody titer
WNV PRN
antibody
titerb
YFV
antigen
WNV
antigen
YFV
antigen
WNV
antigen
31 days after ChimeriVax-WNV
H-8183 1:40 1:160 0c 0 1:160
H-8184 1:40 1:160 0 ND 1:160
H-8185 1:40 1:160 0 1:20 1:640
H-8186 1:80 1:320 0 1:40 1:320
H-8187 1:40 1:160 0 1:20 >1:640
H-8188 1:40 1:160 0 1:20 1:640
H-8189 1:80 1:320 0 1:40 1:640
H-8190 1:40 1:160 0 1:20 1:320
H-8191 1:80 1:160 0 1:20 1:80
H-8192 1:40 1:160 0 1:40 1:80
6 days after challenge with WNV
H-8183 1:20 1:160 0 0 ND
H-8184 1:40 1:160 0 1:40 ND
H-8185 1:20 1:160 0 1:20 ND
H-8186 1:80 1:320 0 1:40 ND
H-8187 1:20 1:160 0 1:20 ND
H-8188 1:40 1:160 0 1:20 ND
H-8189 1:80 1:320 0 1:40 ND
H-8190 1:40 1:320 0 1:40 ND
H-8191 1:40 1:320 0 1:20 ND
H-8192 1:40 1:160 0 1:20 ND

aWNV, West Nile virus; HI, hemagglutination inhibition; CF, complement fixation; PRN, plaque reduction neutralization; YFV, Yellow fever virus; ND, not done.
bHighest serum dilution producing >90% plaque inhibition.
c0 = <1:20.

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