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Volume 8, Number 3—March 2002

Research

Immunization with Heterologous Flaviviruses Protective Against Fatal West Nile Encephalitis

Robert B. TeshComments to Author , Amelia P.A. Travassos da Rosa, Hilda Guzman, Tais P. Araujo, and Shu-Yuan Xiao
Author affiliations: University of Texas Medical Branch, Galveston, Texas, USA;

Main Article

Table 2

Serologic response of adult hamsters to West Nile virus (WNV), Yellow fever virus (YFV), St. Louis encephalitis virus (SLEV), and Japanese encephalitis virus (JEV) antigens, at various intervals after intraperitoneal inoculation of 104.0 TCID50 of WNV

HI antibody titer
Animal no. WNV YFV SLEV JEV WN MAC-ELISA
Day 6
8251(Da) 1:40 0b 0 0 0.633c
8252 1:80 0 0 0 1.013
8253(D) 1:160 0 0 0 0.878
8254 1:160 0 0 0 1.090
8255 1:80 0 0 0 0.848
8256 1:80 0 0 0 0.840
8257(D) 1:160 0 0 0 1.291
8258 1:80 0 0 0 0.869
8259(D) 1:160 0 0 0 0.939
8260 1:80 0 0 0 0.992
8262 1:80 0 0 0 0.748
8263 1:80 0 0 0 0.797
8264(D) 1:80 0 0 0 0.827
Day 31
8252 1:1,280 1:320 1:320 1:320 0.401
8254 1:1,280 1:320 1:320 1:320 0.427
8255 1:640 1:160 1:320 1:160 0.488
8256 1:640 1:160 1:160 1:160 0.582
8258 1:640 1:160 1:160 1:160 0.376
8260 1:1,280 1:320 1:320 1:320 0.420
8262 1:1,280 1:320 1:320 1:320 0.246
8263 1:640 1:160 1:160 1:160 0.516
Day 60
8252 1:2,560 1:640 1:640 1:640 0.269
8255 1:2,560 1:640 1:640 1:640 0.216
8256 1:640 1:160 1:160 1:160 0.162
8258 1:1,280 1:320 1:320 1:320 0.161
8260 1:320 1:80 1:80 1:40 0.179
8262 1:640 1:160 1:160 1:160 0.181
Day 90
8254 1:320 1:80 1:80 1:80 0.167
8260 1:640 1:80 1:80 1:80 0.217
8262 1:640 1:80 1:160 1:160 0.184

a(D): Hamster died of encephalitis 7 to 14 days after infection. HI = hemagglutination inhibition.
b0 <1:20.
cOptical density value (>0.200 is positive).

Main Article

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