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Volume 8, Number 5—May 2002

Research

Excess Mortality Associated with Antimicrobial Drug-Resistant Salmonella Typhimurium

Morten Helms*, Pernille Vastrup*, Peter Gerner-Smidt*, and Kåre Mølbak*Comments to Author 
Author affiliations: *Statens Serum Institut, Copenhagen, Denmark;

Main Article

Table 2

Two-year relative death rate of patients infected with Salmonella Typhimurium, by antimicrobial susceptibility pattern. Registry linkage study including 2,047 patients and a random matched sample of 20,456 people from the Danish general population

Resistant Susceptiblea
Deaths/cases RRb (95% CIc) Deaths/cases RR (95% CI) p-valued
Resistant to >1 drug 31/1,094 2.4 (1.6–3.7) 28/953 2.3 (1.5-3.5) 0.86
Ampicillin 13/393 3.5 (1.7-7.2) 46/1,654 2.1 (1.5-3.0) 0.21
Chloramphenicol 16/347 5.1 (2.6-10.2) 43/1,700 1.9 (1.4-2.8) 0.01
Streptomycin 13/458 2.1 (1.1-4.1) 46/1,589 2.4 (1.7-3.4) 0.76
Sulfonamides 31/969 2.5 (1.6-3.9) 28/1,078 2.1 (1.4-3.3) 0.60
Tetracycline 15/513 2.2 (1.2-4.1) 44/1,534 2.4 (1.7-3.4) 0.85
Kanamycin 3/108 23/1,018 3.9 (2.2-6.7)
Quinolone 5/83 10.3(2.8-37.8) 54/1,964 2.1 (1.6-3.0) 0.02
R-type ACSSuT 12/283 4.8 (2.2-10.5) 47/1,764 2.1 (1.5-2.9) 0.06
R-type ACSSuTNx 5/40 13.1 (3.3-51.9) 7/243e 2.9 (1.1-7.9) 0.09

aSusceptible refers to strains susceptible to the given antimicrobial drugs or combination of antimicrobial drugs; first cell refers to pansusceptible strains.
bDeath rate relative to the general population, as estimated by conditional proportional hazards regression analysis, controlling for underlying illness; RR=rate ratio.
cCI=confidence interval.
dp-value for test of homogeneity, i.e., RR for resistant being the same as for susceptible strains.
eStrains with R-type ACSSuT, but quinolone sensitve.

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