TY - JOUR AU - Hospitals, Project AU - Fridkin, Scott K. AU - Hill, Holly A. AU - Volkova, Nataliya V. AU - Edwards, Jonathan R. AU - Lawton, Rachel M. AU - Gaynes, Robert P. AU - McGowan, John E. T1 - Temporal Changes in Prevalence of Antimicrobial Resistance in 23 U.S. Hospitals T2 - Emerging Infectious Disease journal PY - 2002 VL - 8 IS - 7 SP - 697 SN - 1080-6059 AB - Antimicrobial resistance is increasing in nearly all health-care–associated pathogens. We examined changes in resistance prevalence during 1996–1999 in 23 hospitals by using two statistical methods. When the traditional chi-square test of pooled mean resistance prevalence was used, most organisms appear to have increased in prevalence. However, when a more conservative test that accounts for changes within individual hospitals was used, significant increases in prevalence of resistance were consistently observed only for oxacillin-resistant Staphylococcus aureus, ciprofloxacin-resistant Pseudomonas aeruginosa, and ciprofloxacin- or ofloxacin-resistant Escherichia coli. These increases were significant only in isolates from patients outside intensive-care units (ICU). The increases seen are of concern; differences in factors present outside ICUs, such as excessive quinolone use or inadequate infection-control practices, may explain the observed trends. KW - antibiotic resistance KW - nosocomial infections KW - surveillance KW - epidemiologic methods KW - United States DO - 10.3201/eid0807.010427 UR - https://wwwnc.cdc.gov/eid/article/8/7/01-0427_article ER - End of Reference