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Volume 8, Number 8—August 2002

Research

Antecedent Treatment with Different Antibiotic Agents as a Risk Factor for Vancomycin-Resistant Enterococcus

Yehuda Carmeli*†Comments to Author , George M. Eliopoulos*†, and Matthew H. Samore*†
Author affiliations: *Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA; †Harvard Medical School, Boston, Massachusetts, USA;

Main Article

Table 1

Patient characteristics and matched univariate analysis for isolation of nosocomial vancomycin-resistant enterococci

Variable Cases (%) (233) Control (%) (647) Odds
ratio p value
Agea 61.7 62.3 .999 0.76
Gender (female) 114 (49) 292 (45) 1.2 0.34
Main admitting diagnosis
Orthopedic condition 5 (6.4) 53 (8.2) R R
Cardiovascular condition 49 (21) 236 (36) 0.37 <0.001
Endocrine disorder 6 (2.6) 13 (2) 1.3 0.6
Gastrointestinal disorder 77 (33) 160 (25) 1.7 0.005
Genitourinary disorder 18 (7.7) 35 (5.4) 1.4 0.21
Infectious disease 26 (11) 19 (3) 3.7 <0.001
Hematologic disease 5 (2.1) 12 (1.9) 0.83 0.7
Neurologic disease 18 (7.7) 69 (10.7) 0.72 0.3
Pulmonary disease 19 (8.1) 49 (7.6) 1.1 0.8
Coexisting conditions
Cardiovascular disease 160 (69) 460 (71) 0.85 0.36
Lung disease 32 (14) 88 (14) 1 0.95
Diabetes mellitus 127 (55) 262 (40) 1.9 <0.001
Organ transplant recipient 39 (17) 45 (7) 2.9 <0.001
Renal disease 57 (24) 103 (16) 1.6 0.013
Cancer 25 (11) 93 (14) .71 0.18
AIDS 2 (1) 8 (1) .75 0.7
Hepatobiliary disease 65 (28) 97 (15) 2.5 <0.001
Charlson comorbidity scorea 3.2 2.7 1.114 0.003
Transfer from an institution 84 (36) 243 (37) 0.9 0.56
Surgery 67 (29) 211 (33) 0.55 0.01
Admission to ICU 65 (28) 169 (26) .78 0.38
MRSA
During current admission 18 (8) 16 (2.5) 3.9 0.001
In past year 28 (12) 26 (4) 3.5 <0.001
Clostridium difficile
During current admission 5 (2.1) 10 (1.5) 1.3 0.59
In past year 17 (7.3) 20 (3.1) 2.6 0.006

aContinuous variable.
R, reference group; MRSA, methicillin-resistant Staphylococcus aureus.

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