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Volume 8, Number 8—August 2002

Synopsis

Worldwide Occurrence of Beijing/W Strains of Mycobacterium tuberculosis: A Systematic Review

Judith R. Glynn*Comments to Author , Jennifer Whiteley*, Pablo J. Bifani†, Kristin Kremer, and Dick van Soolingen
Author affiliations: *London School of Hygiene and Tropical Medicine, London, UK; †Institut Pasteur de Lille, France; and ‡National Institute of Public Health and the Environment (RIVM), Bilthoven, the Netherlands;

Main Article

Table 2

Prevalence of Beijing and W-like strains in studies not based on spoligotypinga

Reference Setting Yrs Population New TB or new + old Typing methods and definitions used Prevalence of Beijing strain
N/N (%)
Asia
23 Henan Province, China ? No information given ? RFLP +3.6kb Pvu II fragment 59/64 (92)
23 Philippines ? No information given ? RFLP +3.6kb Pvu II fragment 34/34 (100)
23 Hanoi, Vietnam ? No information given ? RFLP +3.6kb Pvu II fragment 20/50 (40)
23 Korea 1995 No information given ? RFLP +3.6kb Pvu II fragment 99/138 (72)
23 Thailand ? No information given ? RFLP +3.6kb Pvu II fragment 31/49 (63)
24 Bangkok Nonthaburi, Thailand 1994–1995 Patients from 3 hospitals ? how selected. Half extrapulmonary ? Both RFLP + comparison with Dutch database 80/211 (37)
23 Malaysia ? No information given ? RFLP +3.6kb Pvu II fragment 17/48 (35)
25 Malaysia 1993–1994 Random 3% sample from whole population ? Both RFLP “similar” to Beijing family 83/439 (19)
Africa
26 Cape Town, South Africa 1993–1997 Whole population Both RFLP “strain U”, (W-like)
Two closely related patterns only 17/650 (2.6)
USA
27 New York City 1992–1994 Patients from 5 hospitals ? Both RFLP, strain W only 6/302 (2.0)
3 New York City 1990–1995 ? selection method ? Both RFLP, “W-like” 273/1,953 (14)
28 Central Los Angeles 1994–1996 Consecutive patients ? Both RFLP, strain 210 (W-related) 43/162 (27)
29 California 1992–1995 All cases from specific locations ? Both RFLP, strain 210 (W-related) 39/522 (7)
16/546 (3)
2/256 (0.8)
Texas 1993–1995
Colorado 1989–1994
2 United States (excluding NY) and Puerto Rico 1992–1997 All notified cases Both RFLP and/or PCR probe. Multidrug resistant W only 23/104,549 (0.02)
South America
30 Buenaventura, Colombia 1997–1998 34 treatment failure + 73 new
? selection method Both RFLP + PCR probe. “Similar” to W 11/107 (10)
(? 8 in new)

aN/N, number with Beijing strain/total number of patient; ?, not clear from report; the different typing methods are described in the introduction. RFLP restriction fragment length polymorphism (RFLP) using IS6110. Polymerase chain reaction (PCR) probe is a multiplex PCR probe targeted at specific insertions. The 3.6 kb pvuII fragment was identified by IS1081 fingerprinting.

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