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Volume 8, Number 8—August 2002
Synopsis

Worldwide Occurrence of Beijing/W Strains of Mycobacterium tuberculosis: A Systematic Review

Judith R. Glynn*Comments to Author , Jennifer Whiteley*, Pablo J. Bifani†, Kristin Kremer, and Dick van Soolingen
Author affiliations: *London School of Hygiene and Tropical Medicine, London, UK; †Institut Pasteur de Lille, France; and ‡National Institute of Public Health and the Environment (RIVM), Bilthoven, the Netherlands;

Main Article

Table 2

Prevalence of Beijing and W-like strains in studies not based on spoligotypinga

Reference Setting Yrs Population New TB or new + old Typing methods and definitions used Prevalence of Beijing strain
N/N (%)
Asia
23 Henan Province, China ? No information given ? RFLP +3.6kb Pvu II fragment 59/64 (92)
23 Philippines ? No information given ? RFLP +3.6kb Pvu II fragment 34/34 (100)
23 Hanoi, Vietnam ? No information given ? RFLP +3.6kb Pvu II fragment 20/50 (40)
23 Korea 1995 No information given ? RFLP +3.6kb Pvu II fragment 99/138 (72)
23 Thailand ? No information given ? RFLP +3.6kb Pvu II fragment 31/49 (63)
24 Bangkok Nonthaburi, Thailand 1994–1995 Patients from 3 hospitals ? how selected. Half extrapulmonary ? Both RFLP + comparison with Dutch database 80/211 (37)
23 Malaysia ? No information given ? RFLP +3.6kb Pvu II fragment 17/48 (35)
25 Malaysia 1993–1994 Random 3% sample from whole population ? Both RFLP “similar” to Beijing family 83/439 (19)
Africa
26 Cape Town, South Africa 1993–1997 Whole population Both RFLP “strain U”, (W-like)
Two closely related patterns only 17/650 (2.6)
USA
27 New York City 1992–1994 Patients from 5 hospitals ? Both RFLP, strain W only 6/302 (2.0)
3 New York City 1990–1995 ? selection method ? Both RFLP, “W-like” 273/1,953 (14)
28 Central Los Angeles 1994–1996 Consecutive patients ? Both RFLP, strain 210 (W-related) 43/162 (27)
29 California 1992–1995 All cases from specific locations ? Both RFLP, strain 210 (W-related) 39/522 (7)
16/546 (3)
2/256 (0.8)
Texas 1993–1995
Colorado 1989–1994
2 United States (excluding NY) and Puerto Rico 1992–1997 All notified cases Both RFLP and/or PCR probe. Multidrug resistant W only 23/104,549 (0.02)
South America
30 Buenaventura, Colombia 1997–1998 34 treatment failure + 73 new
? selection method Both RFLP + PCR probe. “Similar” to W 11/107 (10)
(? 8 in new)

aN/N, number with Beijing strain/total number of patient; ?, not clear from report; the different typing methods are described in the introduction. RFLP restriction fragment length polymorphism (RFLP) using IS6110. Polymerase chain reaction (PCR) probe is a multiplex PCR probe targeted at specific insertions. The 3.6 kb pvuII fragment was identified by IS1081 fingerprinting.

Main Article

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Page created: July 16, 2010
Page updated: July 16, 2010
Page reviewed: July 16, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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