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Volume 8, Number 8—August 2002

Synopsis

Worldwide Occurrence of Beijing/W Strains of Mycobacterium tuberculosis: A Systematic Review

Judith R. Glynn*Comments to Author , Jennifer Whiteley*, Pablo J. Bifani†, Kristin Kremer, and Dick van Soolingen
Author affiliations: *London School of Hygiene and Tropical Medicine, London, UK; †Institut Pasteur de Lille, France; and ‡National Institute of Public Health and the Environment (RIVM), Bilthoven, the Netherlands;

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Table 3

Association between Beijing family strains of Mycobacterium tuberculosis and drug resistancea

Reference Place, yr Strain
% Drug resistance
Comparison of Beijing vs. non-Beijing by drugb
RR 95% CIb
Beijing Non-Beijing Any
I
S
MDR
Beijing Non-Beijing Beijing Non-Beijing Beijing Non-Beijing Beijing Non-Beijing
13 Hong Kong, 1998–1999 310 181 6 12 10 13 I 0.54 (0.30 to 0.97)
S 0.76 (0.46 to 1.3)
14 Ho Chi Minh City, 1998–1999 264 235 28 19 42 19 3 2 I 1.5 (1.1 to 2.0)
S 2.2 (1.6 to 3.0)
MDR 1.4 (0.47 to 4.3)
15 Bangkok, 1999–2000 90 114 No assoc
8 Jakarta, 1998–1999 27 56 41 25 37 20 15 5 Any 1.6 (0.86 to 3.1)
I 1.9 (0.92 to 3.9)
S 2.8 (0.67 to 11.5)
16 Senegal, 1994–1995 8 61 No assoc
11 NW Russia, 1997–1998 22 78 77 58 MDR 1.3 (1.0 to 1.8)
10 Azerbaijan, 1995–1996 46 19 89 68 80 68 83 58 61 32 Any 1.3 (0.94 to 1.8)
I 1.2 (0.84 to 1.6)
S 1.4 (0.95 to 2.1)
MDR 1.9 (0.96 to 3.9)
18 Estonia, 1994 61 148 70 14 34 2 Any 5.0 (3.2 to 7.6)
MDR 17.0 (5.3 to 54.9)
19 Gran Canaria, 1991–1996 75 576 0 ?
3 New York, 1990–1995 273 (W-like) 1,680 (not W like) 93b ?0 p <0.001
21d Cuba, 1994–1995 20 137 55–65 4–5 55–60 4 0–10 0.7–2 0 0.7 Any 10.8 (4.7 to 24.5)
I 15.1 (5.8 to 38.9)
30 Colombia, 1997–1998 11 70 27 23 MDR 1.2 (0.41 to 3.4)

aI, isoniazid; S, streptomycin; MDR, multidrug resistant (at least isoniazid and rifampicin); blank spaces indicate that data are not available.
bRelative risks (RR) were calculated when possible from the data presented. These are shown with 95% confidence intervals.
c Resistant to at least four drugs. Includes 206 W strains and 40 W1 strains. Identified by RFLP, not spoligotyping.
dExact numbers not clear since drug resistance data only given by strain number for IS6110 defined clusters, and two Beijing strains were not clustered. For the relative risk calculation, the minimum proportion resistant among the Beijing strains was used.

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