Volume 8, Number 8—August 2002
Synopsis
Worldwide Occurrence of Beijing/W Strains of Mycobacterium tuberculosis: A Systematic Review
Judith R. Glynn*
, Jennifer Whiteley*, Pablo J. Bifani†, Kristin Kremer, and Dick van Soolingen
, Jennifer Whiteley*, Pablo J. Bifani†, Kristin Kremer, and Dick van SoolingenTable 3
Association between Beijing family strains of Mycobacterium tuberculosis and drug resistancea
| Reference | Place, yr | Strain |
% Drug resistance |
Comparison of Beijing vs. non-Beijing by drugb RR 95% CIb | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beijing | Non-Beijing | Any |
I |
S |
MDR |
||||||||
| Beijing | Non-Beijing | Beijing | Non-Beijing | Beijing | Non-Beijing | Beijing | Non-Beijing | ||||||
| 13 | Hong Kong, 1998–1999 | 310 | 181 | 6 | 12 | 10 | 13 | I 0.54 (0.30 to 0.97) | |||||
| S 0.76 (0.46 to 1.3) | |||||||||||||
| 14 | Ho Chi Minh City, 1998–1999 | 264 | 235 | 28 | 19 | 42 | 19 | 3 | 2 | I 1.5 (1.1 to 2.0) | |||
| S 2.2 (1.6 to 3.0) | |||||||||||||
| MDR 1.4 (0.47 to 4.3) | |||||||||||||
| 15 | Bangkok, 1999–2000 | 90 | 114 | No assoc | |||||||||
| 8 | Jakarta, 1998–1999 | 27 | 56 | 41 | 25 | 37 | 20 | 15 | 5 | Any 1.6 (0.86 to 3.1) | |||
| I 1.9 (0.92 to 3.9) | |||||||||||||
| S 2.8 (0.67 to 11.5) | |||||||||||||
| 16 | Senegal, 1994–1995 | 8 | 61 | No assoc | |||||||||
| 11 | NW Russia, 1997–1998 | 22 | 78 | 77 | 58 | MDR 1.3 (1.0 to 1.8) | |||||||
| 10 | Azerbaijan, 1995–1996 | 46 | 19 | 89 | 68 | 80 | 68 | 83 | 58 | 61 | 32 | Any 1.3 (0.94 to 1.8) | |
| I 1.2 (0.84 to 1.6) | |||||||||||||
| S 1.4 (0.95 to 2.1) | |||||||||||||
| MDR 1.9 (0.96 to 3.9) | |||||||||||||
| 18 | Estonia, 1994 | 61 | 148 | 70 | 14 | 34 | 2 | Any 5.0 (3.2 to 7.6) | |||||
| MDR 17.0 (5.3 to 54.9) | |||||||||||||
| 19 | Gran Canaria, 1991–1996 | 75 | 576 | 0 | ? | ||||||||
| 3 | New York, 1990–1995 | 273 (W-like) | 1,680 (not W like) | 93b | ?0 | p <0.001 | |||||||
| 21d | Cuba, 1994–1995 | 20 | 137 | 55–65 | 4–5 | 55–60 | 4 | 0–10 | 0.7–2 | 0 | 0.7 | Any 10.8 (4.7 to 24.5) | |
| I 15.1 (5.8 to 38.9) | |||||||||||||
| 30 | Colombia, 1997–1998 | 11 | 70 | 27 | 23 | MDR 1.2 (0.41 to 3.4) | |||||||
aI, isoniazid; S, streptomycin; MDR, multidrug resistant (at least isoniazid and rifampicin); blank spaces indicate that data are not available.
bRelative risks (RR) were calculated when possible from the data presented. These are shown with 95% confidence intervals.
c Resistant to at least four drugs. Includes 206 W strains and 40 W1 strains. Identified by RFLP, not spoligotyping.
dExact numbers not clear since drug resistance data only given by strain number for IS6110 defined clusters, and two Beijing strains were not clustered. For the relative risk calculation, the minimum proportion resistant among the Beijing strains was used.
