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Volume 9, Number 1—January 2003

Research

A Molecular Surveillance System for Global Patterns of Drug Resistance in Imported Malaria

Annie-Claude Labbé*, Samir N. Patel*, Ian Crandall*, and Kevin C. Kain*Comments to Author 
Author affiliations: *Toronto General Hospital, University of Toronto, Canada

Main Article

Table 2

Proportions of falciparum isolates with chloroquine- or sulfadoxine-pyrimethamine-associated resistance markers by year of acquisitiona

Year
Proportions of mutant isolates
Proportions of isolates with at least
2 mutant codons
pfmdr1 (N86Y)b pfcrt (K76T) dhfrc dhpsd
1994
42.9%
9/21
71.4%
15/21
45.5%
10/22
14.3%
3/21
1995
25.0%
2/8
55.6%
5/9
62.5%
5/8
33.3%
3/9
1996
31.6%
6/19
50.0%
9/18
52.4%
11/21
25.0%
5/20
1997
52.9%
9/17
66.7%
10/15
88.2%
15/17
35.3%
6/17
1998
64.3%
9/14
50.0%
7/14
85.7%
12/14
21.4%
3/14
1999
50.0%
7/14
64.3%
9/14
78.6%
11/14
57.1%
8/14
2000e
71.4%
5/7
57.1%
4/7
50.0%
3/6
42.9%
3/7
Total
47.0%
47/100
60.2%
59/98
65.7%
67/102
30.4%
31/102
(95% CI) (36.9 to 57.2) (49.8 to 70.0) (54.6 to 3.9) (21.7 to 40.3)

aOR, odds ratio; CI, confidence interval.

bOR for a 1-unit increase in year = 1.21 (95% CI 0.99 to 1.49); p=0.07, chi-square test for trend.

cOR for a 1-unit increase in year = 1.28 (95% CI 1.0 to 1.59); p=0.02, chi-square test for trend.

dOR for a 1-unit increase in year = 1.29 (95% CI 1.03 to 1.61); p=0.03, chi-square test for trend.

eData for year 2000 are from January 1 to June 30.

Main Article

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