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Volume 9, Number 1—January 2003

Dispatch

Transfusion-Associated Babesiosis after Heart Transplant

Joseph Z. Lux*, Don Weiss†, Jeanne V. Linden‡, Debra Kessler§, Barbara L. Herwaldt¶, Susan J. Wong‡, Jan Keithly‡, Phyllis Della-Latta#, and Brian E. Scully*Comments to Author 
Author affiliations: *Columbia University College of Physicians and Surgeons, New York, New York, USA; †New York City Department of Health, New York, New York, USA; ‡Wadsworth Center, New York State Department of Health, Albany, New York, USA; §New York Blood Center, New York, New York, USA; ¶Centers for Disease Control and Prevention, Atlanta, Georgia, USA; #Columbia Presbyterian Medical Center, New York, New York, USA

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Table

Results of serologic testing, polymerase chain reaction analyses, and hamster injection for specimens from the case-patient with babesiosis and the implicated blood donora

Date of specimen Timing of specimen Test Result of
testing
Case-patient



September 21, 2000
Pretransplant
Babesia microti IFA
<1:8b
November 14, 2000
Posttransplant
B. microti IFA
1:1024
November 14, 2000
Posttransplant
B. microti PCR
Positive
September 21, 2000
Pretransplant
Agent of HGE, IgMc
Negative
November 14, 000
Posttransplant
Agent of HGE, IgM
Negative
September 21, 2000
Pretransplant
Agent of HGE, IgG
Negative
November 14, 2000
Posttransplant
Agent of HGE, IgG
Negative
September 21, 2000
Pretransplant
Ehrlichia chaffeensis IFA
Negative
November 14, 2000
Posttransplant
E. chaffeensis IFA
Negative
September 21, 2000
Pretransplant
Lyme ELFA
Negative
November 14,2000
Posttransplant
Lyme ELFA
Negative
Implicated blood donor (tested approximately 5 months after donation)



February 28, 2001
Postdonation
Babesia microti IFA
1:256
February 28, 2001
Postdonation
B. microti PCR
Negative
February 28, 2001 Postdonation Hamster inoculationd Negative

aIFA, indirect fluorescent antibody; PCR, polymerase chain reaction; HGE, human granulocytic ehrlichiosis; Ig, immunoglobulin; ELFA, enzyme-linked fluorescence assay.
bBabesia microti IFA≤ 1:8=negative.
cIgM and IgG immunoblots for HGE.

dTwo hamsters were each inoculated intraperitoneally on April 3 with 0.75 mL of blood obtained on
February 28. Giemsa-stained smears were made from hamster blood obtained twice weekly, for 8
weeks, by tail snip. The hamsters did not become demonstrably parasitemic

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