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Volume 9, Number 10—October 2003

Research

Cephamycin Resistance in Clinical Isolates and Laboratory-derived Strains of Escherichia coli, Nova Scotia, Canada

Brian Clarke*, Margot Hiltz*, Heather Musgrave*, and Kevin R. Forward*Comments to Author 
Author affiliations: *Dalhousie University and the Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada

Main Article

Table 2

Effect of serial passage on cefoxitin gradient on promoter and attenuator regions and outer membrane protein profiles of laboratory wild type Escherichia colia,b

Strain MIC before serial passage (μg/mL) MIC after serial passage (μg/mL) Outer membrane protein profile
LD1
<2
>32
None
LD2
<2
>32
Omp C-, Omp F-
LD3
<2
16
Omp C-, Omp F-
LD4
<2
>32
Omp C-, Omp F-
LD5
<2
>32
Omp C-, Omp F-
LD6
<2
8
Not done
LD7
<2
4
Not done
LD8
<2
16
Omp C-, Omp F-
LD9
<2
>32
Omp C- , Omp F-
LD10 <2 >32 Decreased production of OmpC/F

aOnly those mutations that arose following serial passage are shown. Some parental strains had mutations initially, which were retained in the mutants.
bNo promoter/attenuator mutations affected β-lactamase production.

Main Article

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