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Volume 9, Number 11—November 2003

Research

Coronavirus-positive Nasopharyngeal Aspirate as Predictor for Severe Acute Respiratory Syndrome Mortality

Owen Tak-Yin Tsang*, Tai-Nin Chau*, Kin-Wing Choi*, Eugene Yuk-Keung Tso*, Wilina Lim†, Ming-Chi Chiu*, Wing-Lok Tong*, Po-Oi Lee*, Bosco Hoi Shiu Lam*, Tak-Keung Ng*, Jak-Yiu Lai*Comments to Author , Wai-Cho Yu*, and Sik-To Lai*Comments to Author 
Author affiliations: *Princess Margaret Hospital, Hong Kong; †Public Health Laboratory Centre, Hong Kong

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Table 2

Vital signs and laboratory findings in 218 patients with severe acute respiratory syndrome

Positive RT-PCR for coronavirus
(n = 156) Negative RT-PCR for coronavirus
(n = 62) p value
Vital sign upon admission
   Temperature (°C) 38.5 ± 0.9 38.4 ± 0.9 0.774
   Heart rate 95 ± 14 98 ± 16 0.571
   Systolic blood pressure 127 ± 18 130 ± 19 0.503
   Diastolic blood pressure 71 ± 11 73 ± 12 0.450
Laboratory findings upon admission
   Hemoglobin level (g/dL) 13.3 ± 1.4 13.0 ± 1.6 0.160
   Leukocyte count (x 109/L) 5.5 ± 2.7 5.5 ± 1.9 0.954
   Neutrophil count (x 109/L) 4.3 ± 2.6 4.2 ± 2.3 0.885
   Lymphocyte count (x 109/L) 0.8 ± 0.3 0.9 ± 0.3 0.045
   Platelet count (x 109/L) 155 ± 55 166 ± 50 0.137
   Prothrombin time (sec) 12 ± 2 12 ± 1 0.396
   Activated partial thromboplastin time (sec) 35 ± 10 33 ± 5 0.094
   Sodium level (mmol/L) 134 ± 4 134 ± 3 0.423
   Potassium level (mmol/L) 3.6 ± 0.5 3.5 ± 0.4 0.787
   Urea level (mmol/L) 3.7 ± 1.8 3.6 ± 4 0.200a
   Creatinine level (mmol/L) 74 ± 19 80 ± 79 0.885a
   Albumin level (g/L) 37± 4 38 ± 5 0.112
   Globulin (g/L) 33 ± 5 33 ± 4 0.737
   Bilirubin (mmol/L) 9 ± 6 8 ± 5 0.798
   Alkaline phosphatase (IU/L) 75 ± 58 67 ± 33 0.245a
   Alanine aminotransferase (IU/L) 43 ± 41 33 ± 30 0.051a
   Creatinine phosphokinase (IU/L) 422 ± 1987 189 ± 391 0.118a
   Lactate dehydrogenase (IU/L) 287 ± 141 208 ± 67 0.001a

aComparison made after log-transformation of data; RT-PCR, reverse transcription polymerase chain reaction; p values in bold are significant.

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