TY - JOUR AU - Sermet-Gaudelus, Isabelle AU - Le Bourgeois, Muriel AU - Pierre-Audigier, Catherine AU - Offredo, Catherine AU - Guillemot, Didier AU - Halley, Sophie AU - Akoua-Koffi, Chantal AU - Vincent, Véronique AU - Sivadon-Tardy, Valérie AU - Ferroni, Agnès AU - Berche, Patrick AU - Scheinmann, Pierre AU - Lenoir, Gérard AU - Gaillard, Jean-Louis T1 - Mycobacterium abscessus and Children with Cystic Fibrosis T2 - Emerging Infectious Disease journal PY - 2003 VL - 9 IS - 12 SP - 1587 SN - 1080-6059 AB - We prospectively studied 298 patients with cystic fibrosis (mean age 11.3 years; range 2 months to 32 years; sex ratio, 0.47) for nontuberculous mycobacteria in respiratory samples from January 1, 1996, to December 31, 1999. Mycobacterium abscessus was by far the most prevalent nontuberculous mycobacterium: 15 patients (6 male, 9 female; mean age 11.9 years; range 2.5–22 years) had at least one positive sample for this microorganism (versus 6 patients positive for M. avium complex), including 10 with >3 positive samples (versus 3 patients for M. avium complex). The M. abscessus isolates from 14 patients were typed by pulsed-field gel electrophoresis: each of the 14 patients harbored a unique strain, ruling out a common environmental reservoir or person-to-person transmission. Water samples collected in the cystic fibrosis center were negative for M. abscessus. This major mycobacterial pathogen in children and teenagers with cystic fibrosis does not appear to be acquired nosocomially. KW - Cystic fibrosis KW - Mycobacterium abscessus KW - nontuberculous mycobacteria KW - hsp65 sequencing KW - pulsed-field gel electrophoresis KW - epidemiology KW - France DO - 10.3201/eid0912.020774 UR - https://wwwnc.cdc.gov/eid/article/9/12/02-0774_article ER - End of Reference