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Volume 9, Number 12—December 2003

Dispatch

Mycobacterium tuberculosis Beijing Genotype and Risk for Treatment Failure and Relapse, Vietnam

Nguyen Thi Ngoc Lan*, Hoang Thi Kim Lien*, Le B. Tung*, Martien W. Borgdorff†‡, Kristin Kremer§, and Dick van Soolingen§Comments to Author 
Author affiliations: *Pham Ngoc Thach Tuberculosis and Lung Diseases Centre, Ho Chi Minh City, Vietnam; †Royal Netherlands Tuberculosis Association, The Hague, the Netherlands; ‡University of Amsterdam, the Netherlands; §National Institute of Public Health and the Environment, Bilthoven, the Netherlands

Main Article

Table

Characteristics at enrollment of case-patients who experienced treatment failure and relapse and of controls who did not experience treatment failure, relapse, or diea

Characteristic Failure
Relapse
All case-patients
Controls
Crude
Adjustedb
Adjustedc
OR 95% CI OR 95% CI OR 95% CI
Sex










Male
28
36
64
104
1



1

Female
12
3
15
39
0.63
0.32 to 1.22


0.55
0.22 to 1.38
Age group (y)










15–34
15
9
24
60
1



1

35–54
22
25
47
72
1.63
0.90 to 3.0


2.0
0.90 to 4.6
>55
3
5
8
11
1.82
0.65 to 5.1


2.4
0.60 to 9.9
Genotype










Beijing
32
29
61
75
2.8
1.48 to 5.15
2.5
1.2 to 5.2
3.2
1.4 to 7.1
Other
8
10
18
61
1

1

1

Unknown



7






Resistance pattern










Fully susc.
4
13
17
101
1

1

1

S only
3
9
12
21
3.4
1.41 to 8.2
4.0
1.6 to 9.9
3.9
1.54 to 9.9
H only
3
4
7
10
4.2
1.39 to 12
4.7
1.5 to 15
5.0
1.54 to 16
Other
30d
13e
43
11
23
10.0 to 54
23
9.7 to 55
26
10.3 to 64
TOTAL 40 39 79 143

a OR, odds ratio; CI, confidence interval; susc., susceptible.
bAdjusted for genotype and resistance pattern.
cAdjusted for age, sex, genotype, and resistance pattern.
dOf these 30, 12 had resistance to H and S, 1 to H, S, and E, 10 to H, R, and S, and 7 to H, R, S, E.
eOf these 13, 11 had resistance to H and S, and 2 to H, S, and E.

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