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Volume 9, Number 12—December 2003

Dispatch

Noninvasive Method for Monitoring Pneumocystis carinii Pneumonia

Michael J. Linke*, Sandy Rebholz†, Margaret Collins†, Reiko Tanaka†, and Melanie T. Cushion*†Comments to Author 
Author affiliations: *Veterans Affairs Medical Center, Cincinnati, Ohio, USA; †University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

Main Article

Table 2

Comparisons of Pneumocystis carinii–specific DNA levels in pre- and postimmunosuppression samples, lung homogenates, and organism numbers in lung homogenates assessed by microscopic enumerationa

Groupsb No. points Spearman r 95% Confidence interval p value Significant
LH Pc DNA vs. post-OS Pc DNA
22
0.5576
0.1648 to 0.7978
0.0070
Yes
LH Pc DNA vs. Pc nuclei
22
0.9035
0.7731 to 0.9606
<0.0001
Yes
Post-OS Pc DNA vs. Pc Nuclei
22
0.4636
0.0388 to 0.7465
0.0298
Yes
Pre-OS Pc DNA vs. post-OS Pc DNA
21*
0.3707
-0.0863 to 0.6988
0.0980
No
Pre-OS Pc DNA vs Pc Nuclei
21
0.4123
-0.0374 to 0.7232
0.0633
No
Pre-OS Pc DNA vs. LH Pc DNA 21 0.2939 -0.1712 to 0.6519 0.1960 No

a21 data points were included in these analyses because 2 rats from the 10-wk group died and 1 preimmunosuppression oral swab sample in the 7-wk group was lost in processing.
bPre-OS Pc DNA, P. carinii –specific DNA from oral swabs taken prior to immunosuppression; post-OS Pc DNA, P. carinii–specific DNA from oral swabs taken at the time of euthanasia; LH Pc DNA, P. carinii–specific DNA from lung homogenates of rats at the 3 different time points; log Pc Nuclei, P. carinii organism number assessed by microscopic enumeration.

Main Article

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