TY - JOUR AU - Bausch, Daniel G. AU - Borchert, Matthias AU - Grein, Thomas AU - Roth, Cathy AU - Swanepoel, Robert AU - Libande, Modeste L. AU - Talarmin, Antoine AU - Bertherat, Eric AU - Muyembe-Tamfum, Jean-Jacques AU - Tugume, Ben AU - Colebunders, Robert AU - Kondé, Kader M. AU - Pirard, Patricia AU - Olinda, Loku L. AU - Rodier, Guénaël R. AU - Campbell, Patricia AU - Tomori, Oyewale AU - Ksiazek, Thomas G. AU - Rollin, Pierre E. T1 - Risk Factors for Marburg Hemorrhagic Fever, Democratic Republic of the Congo T2 - Emerging Infectious Disease journal PY - 2003 VL - 9 IS - 12 SP - 1531 SN - 1080-6059 AB - We conducted two antibody surveys to assess risk factors for Marburg hemorrhagic fever in an area of confirmed Marburg virus transmission in the Democratic Republic of the Congo. Questionnaires were administered and serum samples tested for Marburg-specific antibodies by enzyme-linked immunosorbent assay. Fifteen (2%) of 912 participants in a general village cross-sectional antibody survey were positive for Marburg immunoglobulin G antibody. Thirteen (87%) of these 15 were men who worked in the local gold mines. Working as a miner (odds ratio [OR] 13.9, 95% confidence interval [CI] 3.1 to 62.1) and receiving injections (OR 7.4, 95% CI 1.6 to 33.2) were associated with a positive antibody result. All 103 participants in a targeted antibody survey of healthcare workers were antibody negative. Primary transmission of Marburg virus to humans likely occurred via exposure to a still unidentified reservoir in the local mines. Secondary transmission appears to be less common with Marburg virus than with Ebola virus, the other known filovirus. KW - Marburg virus disease KW - Filoviridae infections KW - Democratic Republic of the Congo KW - cross-sectional studies KW - disease transmission KW - risk factors KW - serology KW - enzyme-linked immunosorbent assay KW - fluorescent antibody technique KW - disease reservoirs KW - Democratic Republic of Congo KW - Congo DO - 10.3201/eid0912.030355 UR - https://wwwnc.cdc.gov/eid/article/9/12/03-0355_article ER - End of Reference