Emerging Infectious Disease ISSN: 1080-6059

Equine Amplification and Virulence of Subtype IE Venezuelan Equine Encephalitis Viruses Isolated during the 1993 and 1996 Mexican Epizootics

Dante Gonzalez*, José G. Estrada-Franco†, Anne-Sophie Carrara†, Judith F. Aronson†, and Scott C. Weaver†

Author affiliations: *Instituto Nacional de Investigaciones Forestales, Agricolas y Pecuarias, Mexico City, Mexico; †University of Texas Medical Branch, Galveston, Texas, USA

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Figure 6

Representative histopathologic changes of brains of infected equines. A. Cerebrum, horse no. 3 (strain OAX131), showing perivascular cuff of lymphocytes (original magnification x200, hematoxylin and eosin [H&E] stain). B. Cerebrum, horse no. 4 (strain CPA201), showing perivascular cuff of lymphocytes (original magnification x200, H&E stain). C. Cerebral gray matter, horse no. 2 (strain OAX131), showing infiltration of mononuclear cells into brain parenchyma (original magnification x200,

Figure 6. Representative histopathologic changes of brains of infected equines. A. Cerebrum, horse no. 3 (strain OAX131), showing perivascular cuff of lymphocytes (original magnification x200, hematoxylin and eosin [H&E] stain). B. Cerebrum, horse no. 4 (strain CPA201), showing perivascular cuff of lymphocytes (original magnification x200, H&E stain). C. Cerebral gray matter, horse no. 2 (strain OAX131), showing infiltration of mononuclear cells into brain parenchyma (original magnification x200, H&E stain), D. cerebral gray matter, horse no. 2, showing numerous eosinophils within perivascular infiltrate (arrow) (original magnification x200, H&E stain).

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