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Volume 9, Number 2—February 2003

Research

Equine Amplification and Virulence of Subtype IE Venezuelan Equine Encephalitis Viruses Isolated during the 1993 and 1996 Mexican Epizootics

Dante Gonzalez*, José G. Estrada-Franco†, Anne-Sophie Carrara†, Judith F. Aronson†, and Scott C. Weaver†Comments to Author 
Author affiliations: *Instituto Nacional de Investigaciones Forestales, Agricolas y Pecuarias, Mexico City, Mexico; †University of Texas Medical Branch, Galveston, Texas, USA

Main Article

Table 2

Outcome for horses experimentally infected with Venezuelan equine encephalitis virus strains

Horse
no. Gender Virus strain Maximum temperature (°C) Maximum viremia levela Clinical outcome Histopathologic findings
1 Male OAX131 40.3 2.8 No disease Perivascular cuffing, minimal encephalitis
2 Male OAX131 40.2 1.4 No disease Perivascular cuffing, minimal encephalitis
3 Male OAX131 39.1 1.4 No disease Perivascular cuffing, minimal encephalitis
4 Male CPA201 40.8 2.4 Fatal encephalitis Perivascular cuffing, lymphocytic meningitis, focal encephalitis
5 Male CPA201 38.4 1.4 No disease Normal
6 Female CPA201 37.7 <0.6 No disease Normal
7 Male OAX142 38.2 <0.6 No disease Normal
8 Female OAX142 38.9 <0.6 No disease Normal
9 Male I-290–93 38.6 <0.6 No disease Normal
10 Male I-290–93 39.8 <0.6 No disease Normal

aTiters expressed as log10 suckling mouse intracerebral lethal dose50/mL serum.

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