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Volume 9, Number 4—April 2003

Perspective

Bacterial Resistance to Penicillin G by Decreased Affinity of Penicillin-Binding Proteins: A Mathematical Model

L. Temime*Comments to Author , P.Y. Boëlle*, P. Courvalin†, and D. Guillemot†
Author affiliations: *Institute National de la Santé et de la Recherdhé, Paris, France; †Unité des Agents Antibactériens, Institut Pasteur, Paris, France

Main Article

Table 2

Sensitivity analysis of the modela

Parameters PRCC
Weighted frequency of treatment
α
0.981651
(Carriage duration) –1
λ
0.672063
(Treatment duration) –1
γ
-0.472343
Contact rate (absence of treatment) β 0.392559

aKey factors that increase (Partial Rank Correlation Coefficient (PRCC>0) or decrease (PRCC<0) the prevalence of penicillin-resistant Streptococcus pneumoniae after 10, starting from an all-susceptible population.

Main Article

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