Volume 9, Number 4—April 2003
Perspective
Bacterial Resistance to Penicillin G by Decreased Affinity of Penicillin-Binding Proteins: A Mathematical Model
L. Temime*
, P.Y. Boëlle*, P. Courvalin†, and D. Guillemot†
, P.Y. Boëlle*, P. Courvalin†, and D. Guillemot†
Table 2
Sensitivity analysis of the modela
| Parameters | PRCC | |
|---|---|---|
| Weighted frequency of treatment |
α |
0.981651 |
| (Carriage duration) –1 |
λ |
0.672063 |
| (Treatment duration) –1 |
γ |
-0.472343 |
| Contact rate (absence of treatment) | β | 0.392559 |
aKey factors that increase (Partial Rank Correlation Coefficient (PRCC>0) or decrease (PRCC<0) the prevalence of penicillin-resistant Streptococcus pneumoniae after 10, starting from an all-susceptible population.
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