TY - JOUR AU - McCaig, Linda F. AU - Besser, Richard E. AU - Hughes, James M. T1 - Antimicrobial-Drug Prescription in Ambulatory Care Settings, United States, 1992–2000 T2 - Emerging Infectious Disease journal PY - 2003 VL - 9 IS - 4 SP - 432 SN - 1080-6059 AB - During the 1990s, as antimicrobial resistance increased among pneumococci, many organizations promoted appropriate antimicrobial use to combat resistance. We analyzed data from the National Ambulatory Medical Care Survey, an annual sample survey of visits to office-based physicians, and the National Hospital Ambulatory Medical Care Survey, an annual sample survey of visits to hospital emergency and outpatient departments, to describe trends in antimicrobial prescribing from 1992 to 2000 in the United States. Approximately 1,100–1,900 physicians reported data from 21,000–37,000 visits; 200–300 outpatient departments reported data for 28,000–35,000 visits; ~400 emergency departments reported data for 21,000–36,000 visits each year. In that period, the population- and visit-based antimicrobial prescribing rates in ambulatory care settings decreased by 23% and 25%, respectively, driven largely by a decrease in prescribing by office-based physicians. Antimicrobial prescribing rates changed as follows: amoxicillin and ampicillin, –43%; cephalosporins, –28%; erythromycin, –76%; azithromycin and clarithromycin, +388%; quinolones, +78%; and amoxicillin/clavulanate, +72%. This increasing use of azithromycin, clarithromycin, and quinolones warrants concern as macrolide- and fluoroquinolone-resistant pneumococci are increasing. KW - antimicrobial drugs KW - prescribing KW - antimicrobial resistance KW - physician offices KW - emergency departments KW - outpatient departments KW - research KW - United States DO - 10.3201/eid0904.020268 UR - https://wwwnc.cdc.gov/eid/article/9/4/02-0268_article ER - End of Reference