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Volume 9, Number 7—July 2003

Research

Mutations in Putative Mutator Genes of Mycobacterium tuberculosis Strains of the W-Beijing Family

Mina Ebrahimi Rad*, Pablo Bifani†, Carlos Martin‡, Kristin Kremer§, Sofia Samper‡, Jean Rauzier*, Barry Kreiswirth¶, Jesus Blazquez#, Marc Jouan*, Dick van Soolingen§, and Brigitte Gicquel*Comments to Author 
Author affiliations: *Institut Pasteur, Paris, France; †Institut Pasteur, Lille, France; ‡Universidad de Zaragoza, Zaragoza, Spain; §National Institute of Public Health and the Environment, Bilthoven, the Netherlands; ¶Public Health Research Institute, Newark, New Jersey, USA; #National Institute of Health, Madrid, Spain

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Table 1

Characteristics of Mycobacterium tuberculosis complex strains originating from 35 different countriesa

Strains Genotype No. isolates Country of isolation Group mutT2 mutT4 ogt
ZA20/65
W-Beijing
2
Spain
1
wt
Arg CGG 48 GGG Gly
Arg CGC 37 Leu CTC
ZA67-69
W-Beijing
3
Spain
1
Gly GGA 58 CGA Arg
Arg CGG 48 GGG Gly
Gly GGG 12 Gly GGA
ZA11/16
Haarlem
2
Spain
2
wt
wt
Thr ACC 15 Ser AGC
ZA12-14/17
other
4
Spain
nd
wt
wt
wt
ZA19
M. bovis
1
Spain

wt
wt
wt
ZA15
other
1
Spain
nd
wt
wt
wt
ZA60-62
W-Beijing
3
Spain
1
wt
Arg CGG 48 GGG Gly
Arg CGC 37 Leu CTC
CDC1551

1
USA
2
wt
wt
wt
H37Rv

1
USA
3
wt
wt
wt
MT210
W-Beijing
1
USA
1
Gly GGA 58 CGA Arg
Arg CGG 48 GGG Gly
Gly GGG 12 Gly GGA
20
W-Beijing
1
Mongolia
1
Gly GGA 58 CGA Arg
Arg CGG 48 GGG Gly
Gly GGG 12 Gly GGA
30
W-Beijing
1
South Africa
1
Gly GGA 58 CGA Arg
Arg CGG 48 GGG Gly
Gly GGG 12 Gly GGA
34
W-Beijing
1
Malaysia
1
Gly GGA 58 CGA Arg
Arg CGG 48 GGG Gly
Gly GGG 12 Gly GGA
43
W-Beijing
1
China
1
Gly GGA 58 CGA Arg
Arg CGG 48 GGG Gly
Gly GGG 12 Gly GGA
44
W-Beijing
1
Thailand
1
Gly GGA 58 CGA Arg
Arg CGG 48 GGG Gly
Gly GGG 12 Gly GGA
45
W-Beijing
1
Malaysia
1
Gly GGA 58 CGA Arg
Arg CGG 48 GGG Gly
Gly GGG 12 Gly GGA
91/102-6
W-Beijing
6
Vietnam
1
Gly GGA 58 CGA Arg
Arg CGG 48 GGG Gly
Gly GGG 12 Gly GGA
110/116/119/124-5/140-2
W-Beijing
8
the Netherlands
1
Gly GGA 58 CGA Arg
Arg CGG 48 GGG Gly
Gly GGG 12 Gly GGA
133
W-Beijing
1
South Africa
1
Gly GGA 58 CGA Arg
Arg CGG 48 GGG Gly
Gly GGG 12 Gly GGA
W4/10/126/129
W-Beijing
4
USA
1
Gly GGA 58 CGA Arg
Arg CGG 48 GGG Gly
Gly GGG 12 Gly GGA
W99
W-Beijing
1
Singapore
1
Gly GGA 58 CGA Arg
Arg CGG 48 GGG Gly
Gly GGG 12 Gly GGA
W147
W-Beijing
1
Russia
1
Gly GGA 58 CGA Arg
Arg CGG 48 GGG Gly
Gly GGG 12 Gly GGA
94
W-Beijing
1
Vietnam
1
wt
Arg CGG 48 GGG Gly
Arg CGC 37 Leu CTC
111
W-Beijing
1
South Korea
1
wt
Arg CGG 48 GGG Gly
Arg CGC 37 Leu CTC
115
W-Beijing
1
the Netherlands
1
wt
Arg CGG 48 GGG Gly
Arg CGC 37 Leu CTC
5107(HG1)
W-Beijing
1
USA
1
wt
Arg CGG 48 GGG Gly
Arg CGC 37 Leu CTC
114, 139
W-Beijing
1
the Netherlands
1
wt
Arg CGG 48 GGG Gly
wt
166(HD6)
W-Beijing
1
USA
1
wt
Arg CGG 48 GGG Gly
wt
165(001)
W-Beijing
1
USA
1
wt
wt
Arg CGC 37 Leu CTC
107(LB)
W-Beijing
1
USA
1
wt
wt
wt
113
W-Beijing
1
the Netherlands
1
wt
wt
wt
122(CI1)
W-Beijing
1
USA
1
wt
wt
wt
IK/KY/LB2/DV/DU2/HI
W-Beijing
6
Russia
1
wt
wt
wt
N16
W-Beijing
1
USA
1
wt
wt
wt
AM W-Beijing 1 USA 1 wt wt wt

awt, wild-type alleles (identical to H37Rv strain); nd, not determined.

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