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Volume 9, Number 8—August 2003

Dispatch

Fluid Intake and Decreased Risk for Hospitalization for Dengue Fever, Nicaragua

Eva Harris*Comments to Author , Leonel Pérez†, Christina R. Phares*, Maria de los Angeles Pérez‡, Wendy Idiaquez‡, Julio Rocha§, Ricardo Cuadra§, Emelina Hernandez¶, Luisa Amanda Campos†, Alcides Gonzalez†, Juan Jose Amador†, and Angel Balmaseda†
Author affiliations: *University of California, Berkeley, California, USA; †Ministerio de Salud, Managua, Nicaragua; ‡Hospital Infantil Manuel de Jesús Rivera, Managua, Nicaragua; §Hospital Escuela Oscar Danilo Rosales Argüello, Leon, Nicaragua; ¶Centro de Salud Francisco Buitrago, Managua, Nicaragua

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Table 2

Crude and adjusted odds ratios and 95% confidence intervals for factors potentially associated with hospitalization for classic dengue fever or dengue fever with hemorrhagic manifestations

Children (<15 years of age)a Older adolescents and adults
(>15 years of age)a
Characteristic No. of patientsb OR (95% CI)c
Crude OR (95% CI)c
Adjustedd # of patientsb OR (95% CI)c
Crude OR (95% CI)c
Adjustedf
Fluid intake during 24-h period before presentation 587 405
  For each additional glass 0.68 (0.62 to 0.75) 0.74 (0.66 to 0.83) 0.67 (0.5 to 0.79) 0.71 (0.59 to 0.85)
  >5 glasses 0.14 (0.08 to 0.25) 0.19 (0.09 to 0.39)e 0.16 (0.06 to 0.43) 0.20 (0.07 to 0.57)g
Age 719 h 464
  For each additional year 0.93 (0.8 to 0.97) 0.98 (0.96 to 1.00)
Sex 718 464
  Male 395 1.43 (1.06 to 1.94) 291 1.27 (0.74 to 2.17)
  Female 323 173
Distance from healthcare facility 701 460
  For each additional 5 km 2.13 (1.68 to 2.69) 1.46 (1.12 to 1.91) 1.16 (0.92 to 1.46)
Date of onset of symptoms 709 455
  For each additional month 1.26 (1.16 to 1.37) 1.51 (1.26 to 1.81) 1.87 (1.53 to 2.29) 2.08 (1.53 to 2.83)
Days between onset of symptoms and being seen at facility 713 457
  For each additional day 1.04 (1.0 to 1.07) 0.98 (0.93 to 1.03)
Thrombocytopenia 499 227
  Yes 189 6.5 (4.25 to 9.96) 6.16 (3.57 to 10.64) 33 3.31 (1.53 to 7.15) 3.62 (1.24 to 10.52)
  No 310 194
Stomach pain 681 439
  Yes 370 0.94 (0.69 to 1.28) 216 1.50 (0.89 to 2.56)
  No 311 223

aThe age distribution of children <15 years of age was 7.2 (SD 3.9) with a range from 0 to 14 years and that of older adolescents and adults was 30.6 (SD 13.9) with a range of 15 to 85 years.
bThe numbers differ based on completeness of information for each variable.
cOR, odds ratios; CI, 95% confidence intervals.
dAdjusted for glasses of liquid consumed (continuous variable), distance from healthcare facility, date of onset of symptoms, and thrombocytopenia.
eThe adjusted OR and 95% CI for glasses of liquid consumed (dichotomous variable) were obtained from a separate model that adjusted for the same factors as footnote d.
fAdjusted for glasses of liquid consumed (continuous variable), date of onset of symptoms, and thrombocytopenia.
gThe adjusted OR and 95% CI for glasses of liquid consumed (dichotomous variable) were obtained from a separate model that adjusted for the same factors as footnote f.
h Dash indicates that this variable did not significantly contribute to the multivariate model.

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